Sandbox Reserved 1759: Difference between revisions
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The protein of interest is the enzyme <scene name='93/934003/Protein_of_interest/1'>mevalonate 3,5-bisphosphate decarboxylase (MBD)</scene> from ''Picrophilus torrid'', a thermoacidophilic archeaon. The MBD enzyme is an important intermediate of the mevalonate (MVA) pathway, specifically as a catalytic enzyme in the MBD reaction. The function of MBD is to catalyze the removal of the phosphate group from the 3rd carbon of mevalonate 3,5-bisphosphate (MVA3,5BP). The enzyme also accompanies the decarboxylation of the substrate. MBD acts upon MVA3,5BP to produce isopentnyl phosphate (IP), PO4, and CO2 in the MBD reaction. | The protein of interest is the enzyme <scene name='93/934003/Protein_of_interest/1'>mevalonate 3,5-bisphosphate decarboxylase (MBD)</scene> from ''Picrophilus torrid'', a thermoacidophilic archeaon. The MBD enzyme is an important intermediate of the mevalonate (MVA) pathway, specifically as a catalytic enzyme in the MBD reaction. The function of MBD is to catalyze the removal of the phosphate group from the 3rd carbon of mevalonate 3,5-bisphosphate (MVA3,5BP). The enzyme also accompanies the decarboxylation of the substrate. MBD acts upon MVA3,5BP to produce isopentnyl phosphate (IP), PO4, and CO2 in the MBD reaction. | ||
== Biological relevance and broader implications == | == Biological relevance and broader implications == | ||
The MVA pathway is an essential metabolic pathway and major source of intermediates for the biosynthesis of isoprenoids in | The MVA pathway is an essential metabolic pathway and major source of intermediates for the biosynthesis of isoprenoids in archael organisms. Isoprenoids are the largest family of natural compounds, with ofer 80,000 chemicals. By understanding the effects of the MBD enzyme and the corresponding homologous enzymes in the MVA pathway, scientists can gain a better understanding of the evolutionary route the metabolic pathway took and it's regulatory functionality. Through mutagenesis of MBD, scientist were able to evaluate the catalytic importance of important amino acids amongst homologous enzymes in other MVA pathways that emerged from divergent evolution. More research will only provide more insite into how the pathway has evolved. | ||
== Important amino acids== | == Important amino acids== | ||
