Sandbox Reserved 1761: Difference between revisions
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This is a default text for your page ''''''. Click above on '''edit this page''' to modify. Be careful with the < and > signs. | This is a default text for your page ''''''. Click above on '''edit this page''' to modify. Be careful with the < and > signs. | ||
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue. | You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue. | ||
[[Image:GABA.png|300 px|thumb|right|y-aminobutyric acid (GABA)]] | |||
== Function of your protein == | == Function of your protein == | ||
The specific function of <scene name='93/934005/Spin/2'>Human ornithine aminotransferase</scene> (''h''OAT) is that of an enzyme. It can be found in humans, as well as mice and pigs. It helps transfer L-ornithine’s δ-amino group to α-ketoglutarate (α-KG). <ref>https://doi.org/10.1016/j.jbc.2022.101969</ref> There is a lack of understanding in regards to ''h''OAT's catalytic mechanism, even though it is a key component of human metabolism. As noted in the article, ''h''OAT operates on a "Bi-Bi, Ping-Pong" kinetic mechanism resulting in the first part of the reaction undergoing a conversion of PLP -> PMP and L-Orn -> L-GSA. Then PMP's amino group is catalyzed by ''h''OAT creating an α-KG. | The specific function of <scene name='93/934005/Spin/2'>Human ornithine aminotransferase</scene> (''h''OAT) is that of an enzyme. It can be found in humans, as well as mice and pigs. It helps transfer L-ornithine’s δ-amino group to α-ketoglutarate (α-KG). <ref>https://doi.org/10.1016/j.jbc.2022.101969</ref> There is a lack of understanding in regards to ''h''OAT's catalytic mechanism, even though it is a key component of human metabolism. As noted in the article, ''h''OAT operates on a "Bi-Bi, Ping-Pong" kinetic mechanism resulting in the first part of the reaction undergoing a conversion of PLP -> PMP and L-Orn -> L-GSA. Then PMP's amino group is catalyzed by ''h''OAT creating an α-KG. | ||
[[Image:Daba.png|300 px|thumb|right|L-2,4-diaminobutyric acid(DABA)]] | |||
== Biological relevance and broader implications == | == Biological relevance and broader implications == | ||
