7t0q: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 7t0q is ~~ON HOLD until Paper Publication~~

==human triosephosphate isomerase mutant v154m==

~~Authors~~: ~~Romero~~, J.M.

== Structural highlights ==

<table><tr><td colspan='2'>[[7t0q]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7T0Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7T0Q FirstGlance]. <br>

~~Description~~: ~~human~~ triosephosphate isomerase ~~mutant v154m~~

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=PGA:2-PHOSPHOGLYCOLIC+ACID'>PGA</scene></td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7t0q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7t0q OCA], [https://pdbe.org/7t0q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7t0q RCSB], [https://www.ebi.ac.uk/pdbsum/7t0q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7t0q ProSAT]</span></td></tr>

[[Category: Romero~~, J.M~~]]

</table>

== Disease ==

[https://www.uniprot.org/uniprot/TPIS_HUMAN TPIS_HUMAN] Defects in TPI1 are the cause of triosephosphate isomerase deficiency (TPI deficiency) [MIM:[https://omim.org/entry/190450 190450]. TPI deficiency is an autosomal recessive disorder. It is the most severe clinical disorder of glycolysis. It is associated with neonatal jaundice, chronic hemolytic anemia, progressive neuromuscular dysfunction, cardiomyopathy and increased susceptibility to infection.

== Function ==

[https://www.uniprot.org/uniprot/TPIS_HUMAN TPIS_HUMAN]

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Romero JM]]

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 7t0q is ON HOLD  until Paper Publication
+==human triosephosphate isomerase mutant v154m==
+<StructureSection load='7t0q' size='340' side='right'caption='[[7t0q]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
-Authors: Romero, J.M.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[7t0q]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7T0Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7T0Q FirstGlance]. <br>
-Description: human triosephosphate isomerase mutant v154m
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=PGA:2-PHOSPHOGLYCOLIC+ACID'>PGA</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7t0q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7t0q OCA], [https://pdbe.org/7t0q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7t0q RCSB], [https://www.ebi.ac.uk/pdbsum/7t0q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7t0q ProSAT]</span></td></tr>
-[[Category: Romero, J.M]]
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/TPIS_HUMAN TPIS_HUMAN] Defects in TPI1 are the cause of triosephosphate isomerase deficiency (TPI deficiency) [MIM:[https://omim.org/entry/190450 190450]. TPI deficiency is an autosomal recessive disorder. It is the most severe clinical disorder of glycolysis. It is associated with neonatal jaundice, chronic hemolytic anemia, progressive neuromuscular dysfunction, cardiomyopathy and increased susceptibility to infection.
+== Function ==
+[https://www.uniprot.org/uniprot/TPIS_HUMAN TPIS_HUMAN]
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Romero JM]]