7x1r: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 7x1r is ~~ON HOLD until Paper Publication~~

==Cryo-EM structure of human thioredoxin reductase bound by Au==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[7x1r]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7X1R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7X1R FirstGlance]. <br>

~~Description~~:

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AU:GOLD+ION'>AU</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7x1r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7x1r OCA], [https://pdbe.org/7x1r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7x1r RCSB], [https://www.ebi.ac.uk/pdbsum/7x1r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7x1r ProSAT]</span></td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/TRXR1_HUMAN TRXR1_HUMAN] Isoform 1 may possess glutaredoxin activity as well as thioredoxin reductase activity and induces actin and tubulin polymerization, leading to formation of cell membrane protrusions. Isoform 4 enhances the transcriptional activity of estrogen receptors alpha and beta while isoform 5 enhances the transcriptional activity of the beta receptor only. Isoform 5 also mediates cell death induced by a combination of interferon-beta and retinoic acid.<ref>PMID:9774665</ref> <ref>PMID:8577704</ref> <ref>PMID:15199063</ref> <ref>PMID:18042542</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Cao P]]

[[Category: Cao SH]]

[[Category: Gao XY]]

[[Category: Gong Y]]

[[Category: He B]]

[[Category: He ZS]]

[[Category: Jiang HD]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 7x1r is ON HOLD  until Paper Publication
+==Cryo-EM structure of human thioredoxin reductase bound by Au==
+<StructureSection load='7x1r' size='340' side='right'caption='[[7x1r]], [[Resolution|resolution]] 3.90&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[7x1r]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7X1R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7X1R FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AU:GOLD+ION'>AU</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7x1r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7x1r OCA], [https://pdbe.org/7x1r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7x1r RCSB], [https://www.ebi.ac.uk/pdbsum/7x1r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7x1r ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/TRXR1_HUMAN TRXR1_HUMAN] Isoform 1 may possess glutaredoxin activity as well as thioredoxin reductase activity and induces actin and tubulin polymerization, leading to formation of cell membrane protrusions. Isoform 4 enhances the transcriptional activity of estrogen receptors alpha and beta while isoform 5 enhances the transcriptional activity of the beta receptor only. Isoform 5 also mediates cell death induced by a combination of interferon-beta and retinoic acid.<ref>PMID:9774665</ref> <ref>PMID:8577704</ref> <ref>PMID:15199063</ref> <ref>PMID:18042542</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Cao P]]
+[[Category: Cao SH]]
+[[Category: Gao XY]]
+[[Category: Gong Y]]
+[[Category: He B]]
+[[Category: He ZS]]
+[[Category: Jiang HD]]