8f7w: Difference between revisions

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'''Unreleased structure'''


The entry 8f7w is ON HOLD
==Gi bound kappa-opioid receptor in complex with dynorphin==
 
<StructureSection load='8f7w' size='340' side='right'caption='[[8f7w]], [[Resolution|resolution]] 3.19&Aring;' scene=''>
Authors: Wang, Y., Zhuang, Y., DiBerto, J.F., Zhou, X.E., Schmitz, G.P., Yuan, Q., Jain, M.K., Liu, W., Melcher, K., Jiang, Y., Roth, B.L., Xu, H.E.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[8f7w]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus], [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8F7W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8F7W FirstGlance]. <br>
Description: Gi bound kappa-opioid receptor in complex with dynorphin
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8f7w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8f7w OCA], [https://pdbe.org/8f7w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8f7w RCSB], [https://www.ebi.ac.uk/pdbsum/8f7w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8f7w ProSAT]</span></td></tr>
[[Category: Zhou, X.E]]
</table>
[[Category: Xu, H.E]]
== Function ==
[[Category: Jain, M.K]]
[https://www.uniprot.org/uniprot/OPRK_HUMAN OPRK_HUMAN] G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions.<ref>PMID:12004055</ref> <ref>PMID:22437504</ref> <ref>PMID:7624359</ref> <ref>PMID:8060324</ref>
[[Category: Melcher, K]]
== References ==
[[Category: Liu, W]]
<references/>
[[Category: Diberto, J.F]]
__TOC__
[[Category: Jiang, Y]]
</StructureSection>
[[Category: Wang, Y]]
[[Category: Bos taurus]]
[[Category: Zhuang, Y]]
[[Category: Homo sapiens]]
[[Category: Roth, B.L]]
[[Category: Large Structures]]
[[Category: Yuan, Q]]
[[Category: Rattus norvegicus]]
[[Category: Schmitz, G.P]]
[[Category: Synthetic construct]]
[[Category: DiBerto JF]]
[[Category: Jain MK]]
[[Category: Jiang Y]]
[[Category: Liu W]]
[[Category: Melcher K]]
[[Category: Roth BL]]
[[Category: Schmitz GP]]
[[Category: Wang Y]]
[[Category: Xu HE]]
[[Category: Yuan Q]]
[[Category: Zhou XE]]
[[Category: Zhuang Y]]
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