8gsd: Difference between revisions
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==Echovirus3 full particle in complex with 6D10 Fab== | |||
<StructureSection load='8gsd' size='340' side='right'caption='[[8gsd]], [[Resolution|resolution]] 3.10Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8gsd]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Echovirus_E3 Echovirus E3] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8GSD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8GSD FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SPH:SPHINGOSINE'>SPH</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8gsd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8gsd OCA], [https://pdbe.org/8gsd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8gsd RCSB], [https://www.ebi.ac.uk/pdbsum/8gsd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8gsd ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/A0A291S400_9ENTO A0A291S400_9ENTO] Component of immature procapsids, which is cleaved into capsid proteins VP4 and VP2 after maturation (By similarity). Allows the capsid to remain inactive before the maturation step.[ARBA:ARBA00025202] | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Echovirus 3 (E3), a serotype of human enterovirus B (HEV-B), causes severe diseases in infants. Here, we determined the structures of E3 with a monoclonal antibody (MAb) 6D10 by cryo-EM to comprehensively understand the specificities and the immunological characteristic of this serotype. The solved cryo-EM structures of the F-, A-, and E-particles of E3 bound with 6D10 revealed the structural features of the virus-antibody interface. Importantly, the structures of E-particles bound with 6D10 revealed for the first time the nature of the C-terminus of VP1 for HEV-Bs at the structural level. The highly immunogenic nature of this region in the E-particles provides new strategies for vaccine development for HEV-Bs. | |||
Structural Basis for the Immunogenicity of the C-Terminus of VP1 of Echovirus 3 Revealed by the Binding of a Neutralizing Antibody.,Qi S, Fu W, Fan J, Zhang L, Zheng B, Wang K, Wang X, Zhu L, Li X, Zhang Y Viruses. 2022 Oct 22;14(11):2322. doi: 10.3390/v14112322. PMID:36366420<ref>PMID:36366420</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
[[Category: Fu | <div class="pdbe-citations 8gsd" style="background-color:#fffaf0;"></div> | ||
[[Category: Wang | == References == | ||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Echovirus E3]] | |||
[[Category: Large Structures]] | |||
[[Category: Mus musculus]] | |||
[[Category: Fu W]] | |||
[[Category: Wang X]] | |||
Revision as of 10:12, 14 December 2022
Echovirus3 full particle in complex with 6D10 Fab
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