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==Crystal structure of human AR complexed with NADP+ and {5-chloro-2-[(2-fluoro-4-iodobenzyl)carbamoyl]phenoxy}acetic acid==
==Crystal structure of human AR complexed with NADP+ and {5-chloro-2-[(2-fluoro-4-iodobenzyl)carbamoyl]phenoxy}acetic acid==
<StructureSection load='4lb3' size='340' side='right' caption='[[4lb3]], [[Resolution|resolution]] 0.80&Aring;' scene=''>
<StructureSection load='4lb3' size='340' side='right'caption='[[4lb3]], [[Resolution|resolution]] 0.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4lb3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LB3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LB3 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4lb3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LB3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LB3 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=M15:{5-CHLORO-2-[(2-FLUORO-4-IODOBENZYL)CARBAMOYL]PHENOXY}ACETIC+ACID'>M15</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=M15:{5-CHLORO-2-[(2-FLUORO-4-IODOBENZYL)CARBAMOYL]PHENOXY}ACETIC+ACID'>M15</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1us0|1us0]], [[2iki|2iki]], [[4lau|4lau]], [[4laz|4laz]], [[4lb4|4lb4]], [[4lbr|4lbr]], [[4lbs|4lbs]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4lb3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lb3 OCA], [https://pdbe.org/4lb3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4lb3 RCSB], [https://www.ebi.ac.uk/pdbsum/4lb3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4lb3 ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">AKR1B1, ALDR1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aldehyde_reductase Aldehyde reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.21 1.1.1.21] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4lb3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lb3 OCA], [http://pdbe.org/4lb3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4lb3 RCSB], [http://www.ebi.ac.uk/pdbsum/4lb3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4lb3 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/ALDR_HUMAN ALDR_HUMAN]] Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.  
[https://www.uniprot.org/uniprot/ALDR_HUMAN ALDR_HUMAN] Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4lb3" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4lb3" style="background-color:#fffaf0;"></div>
==See Also==
*[[Aldose reductase 3D structures|Aldose reductase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Aldehyde reductase]]
[[Category: Homo sapiens]]
[[Category: Human]]
[[Category: Large Structures]]
[[Category: Cousido-Siah, A]]
[[Category: Cousido-Siah A]]
[[Category: Fanfrlik, J]]
[[Category: Fanfrlik J]]
[[Category: Hobza, P]]
[[Category: Hobza P]]
[[Category: Kolar, M]]
[[Category: Kolar M]]
[[Category: Mitschler, A]]
[[Category: Mitschler A]]
[[Category: Podjarny, A]]
[[Category: Podjarny A]]
[[Category: Ruiz, F X]]
[[Category: Ruiz FX]]
[[Category: Aldose reductase]]
[[Category: Cytosolic]]
[[Category: Diabetes]]
[[Category: Halogenated compound]]
[[Category: Oxidoreductase]]
[[Category: Tim barrel]]
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