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==Crystal Structure of Ebola virus VP40 Hexamer==
==Crystal Structure of Ebola virus VP40 Hexamer==
<StructureSection load='4ldd' size='340' side='right' caption='[[4ldd]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
<StructureSection load='4ldd' size='340' side='right'caption='[[4ldd]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4ldd]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Zebov Zebov]. The October 2014 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Ebola Virus Proteins''  by David Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2014_10 10.2210/rcsb_pdb/mom_2014_10]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LDD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LDD FirstGlance]. <br>
<table><tr><td colspan='2'>[[4ldd]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Zaire_ebolavirus Zaire ebolavirus]. The October 2014 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Ebola Virus Proteins''  by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2014_10 10.2210/rcsb_pdb/mom_2014_10]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LDD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LDD FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ld8|4ld8]], [[4ldb|4ldb]], [[4ldi|4ldi]], [[4ldm|4ldm]]</td></tr>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ldd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ldd OCA], [https://pdbe.org/4ldd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ldd RCSB], [https://www.ebi.ac.uk/pdbsum/4ldd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ldd ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">VP40 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=186538 ZEBOV])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ldd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ldd OCA], [http://pdbe.org/4ldd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ldd RCSB], [http://www.ebi.ac.uk/pdbsum/4ldd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ldd ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/VP40_EBOZM VP40_EBOZM]] Promotes virus assembly and budding by interacting with host proteins of the multivesicular body pathway. May facilitate virus budding by interacting with the nucleocapsid and the plasma membrane. Specific interactions with membrane-associated GP and VP24 during the budding process may also occur. The hexamer form seems to be involved in budding. The octamer form binds RNA, and may play a role in genome replication.<ref>PMID:15892969</ref> <ref>PMID:16719918</ref>
[https://www.uniprot.org/uniprot/VP40_EBOZM VP40_EBOZM] Promotes virus assembly and budding by interacting with host proteins of the multivesicular body pathway. May facilitate virus budding by interacting with the nucleocapsid and the plasma membrane. Specific interactions with membrane-associated GP and VP24 during the budding process may also occur. The hexamer form seems to be involved in budding. The octamer form binds RNA, and may play a role in genome replication.<ref>PMID:15892969</ref> <ref>PMID:16719918</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Ebola Virus Proteins]]
[[Category: Ebola Virus Proteins]]
[[Category: Large Structures]]
[[Category: RCSB PDB Molecule of the Month]]
[[Category: RCSB PDB Molecule of the Month]]
[[Category: Zebov]]
[[Category: Zaire ebolavirus]]
[[Category: Ableson, D M]]
[[Category: Ableson DM]]
[[Category: Bornholdt, Z A]]
[[Category: Bornholdt ZA]]
[[Category: Saphire, E O]]
[[Category: Saphire EO]]
[[Category: Ebolavirus matrix assembly]]
[[Category: Viral protein]]
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