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==Crystal structure of Reston Ebola virus VP35 RNA binding domain bound to 12-bp dsRNA==
==Crystal structure of Reston Ebola virus VP35 RNA binding domain bound to 12-bp dsRNA==
<StructureSection load='4lg2' size='340' side='right' caption='[[4lg2]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
<StructureSection load='4lg2' size='340' side='right'caption='[[4lg2]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4lg2]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Eborr Eborr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LG2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LG2 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4lg2]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Reston_ebolavirus_-_Reston_(1989) Reston ebolavirus - Reston (1989)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LG2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LG2 FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3ks8|3ks8]], [[3fke|3fke]], [[3l25|3l25]], [[4gha|4gha]], [[3l26|3l26]]</td></tr>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4lg2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lg2 OCA], [https://pdbe.org/4lg2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4lg2 RCSB], [https://www.ebi.ac.uk/pdbsum/4lg2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4lg2 ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">VP35, REBOVgp2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=386032 EBORR])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4lg2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lg2 OCA], [http://pdbe.org/4lg2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4lg2 RCSB], [http://www.ebi.ac.uk/pdbsum/4lg2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4lg2 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/VP35_EBORR VP35_EBORR]] Acts as a polymerase cofactor in the RNA polymerase transcription and replication complex. Prevents establishment of cellular antiviral state by blocking virus-induced phosphorylation and activation of interferon regulatory factor 3 (IRF3), a transcription factor critical for the induction of interferons alpha and beta. The mechanism by which this blockage occurs remains incompletely defined, a hypothesis suggests that VP35 dsRNA-binding activity prevents activation of IRF3 by sequestering dsRNA. Also inhibits the antiviral effect mediated by the interferon-induced, double-stranded RNA-activated protein kinase EIF2AK2/PKR (By similarity).  
[https://www.uniprot.org/uniprot/VP35_EBORR VP35_EBORR] Acts as a polymerase cofactor in the RNA polymerase transcription and replication complex. Prevents establishment of cellular antiviral state by blocking virus-induced phosphorylation and activation of interferon regulatory factor 3 (IRF3), a transcription factor critical for the induction of interferons alpha and beta. The mechanism by which this blockage occurs remains incompletely defined, a hypothesis suggests that VP35 dsRNA-binding activity prevents activation of IRF3 by sequestering dsRNA. Also inhibits the antiviral effect mediated by the interferon-induced, double-stranded RNA-activated protein kinase EIF2AK2/PKR (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Eborr]]
[[Category: Large Structures]]
[[Category: Bale, S]]
[[Category: Bale S]]
[[Category: Bornholdt, Z A]]
[[Category: Bornholdt ZA]]
[[Category: Julien, J P]]
[[Category: Julien J-P]]
[[Category: Krois, A S]]
[[Category: Krois AS]]
[[Category: Saphire, E O]]
[[Category: Saphire EO]]
[[Category: Wilson, I A]]
[[Category: Wilson IA]]
[[Category: Dsrna]]
[[Category: Dsrna binding protein]]
[[Category: Rna binding domain]]
[[Category: Rna binding protein-rna complex]]
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