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==Crystal Structures of Lgr4 and its complex with R-spondin1==
==Crystal Structures of Lgr4 and its complex with R-spondin1==
<StructureSection load='4li1' size='340' side='right' caption='[[4li1]], [[Resolution|resolution]] 2.66&Aring;' scene=''>
<StructureSection load='4li1' size='340' side='right'caption='[[4li1]], [[Resolution|resolution]] 2.66&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4li1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Silurana_(xenopus)_tropicalis Silurana (xenopus) tropicalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LI1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LI1 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4li1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Xenopus_tropicalis Xenopus tropicalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LI1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LI1 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4li2|4li2]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4li1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4li1 OCA], [https://pdbe.org/4li1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4li1 RCSB], [https://www.ebi.ac.uk/pdbsum/4li1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4li1 ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">lgr4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=8364 Silurana (Xenopus) tropicalis])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4li1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4li1 OCA], [http://pdbe.org/4li1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4li1 RCSB], [http://www.ebi.ac.uk/pdbsum/4li1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4li1 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/LGR4_XENTR LGR4_XENTR]] Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and is involved in the formation of various organs. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Its function as activator of the Wnt signaling pathway is required for the development of various organs, including liver, kidney, intestine, bone, reproductive tract and eye.  
[https://www.uniprot.org/uniprot/LGR4_XENTR LGR4_XENTR] Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and is involved in the formation of various organs. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Its function as activator of the Wnt signaling pathway is required for the development of various organs, including liver, kidney, intestine, bone, reproductive tract and eye.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Rajashankar, K]]
[[Category: Large Structures]]
[[Category: Robev, D]]
[[Category: Xenopus tropicalis]]
[[Category: Xu, Y]]
[[Category: Rajashankar K]]
[[Category: Hormone receptor]]
[[Category: Robev D]]
[[Category: Lrr]]
[[Category: Xu Y]]
Retrieved from "https://proteopedia.org/4li1"