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==Neutron structure of the cyclic glucose bound Xylose Isomerase E186Q mutant==
==Neutron structure of the cyclic glucose bound Xylose Isomerase E186Q mutant==
<StructureSection load='4lnc' size='340' side='right' caption='[[4lnc]], [[Resolution|resolution]] 2.19&Aring;' scene=''>
<StructureSection load='4lnc' size='340' side='right'caption='[[4lnc]], [[Resolution|resolution]] 2.19&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4lnc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"actinomyces_rubiginosus"_preobrazhenskaya_et_al._in_gauze_et_al._1957 "actinomyces rubiginosus" preobrazhenskaya et al. in gauze et al. 1957]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LNC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LNC FirstGlance]. <br>
<table><tr><td colspan='2'>[[4lnc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_rubiginosus Streptomyces rubiginosus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LNC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LNC FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DOD:DEUTERATED+WATER'>DOD</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DOD:DEUTERATED+WATER'>DOD</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">xylA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1929 "Actinomyces rubiginosus" Preobrazhenskaya et al. in Gauze et al. 1957])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4lnc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lnc OCA], [https://pdbe.org/4lnc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4lnc RCSB], [https://www.ebi.ac.uk/pdbsum/4lnc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4lnc ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Xylose_isomerase Xylose isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.1.5 5.3.1.5] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4lnc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lnc OCA], [http://pdbe.org/4lnc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4lnc RCSB], [http://www.ebi.ac.uk/pdbsum/4lnc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4lnc ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/XYLA_STRRU XYLA_STRRU]] Involved in D-xylose catabolism.  
[https://www.uniprot.org/uniprot/XYLA_STRRU XYLA_STRRU] Involved in D-xylose catabolism.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Actinomyces rubiginosus preobrazhenskaya et al. in gauze et al. 1957]]
[[Category: Large Structures]]
[[Category: Xylose isomerase]]
[[Category: Streptomyces rubiginosus]]
[[Category: Meilleur, F]]
[[Category: Meilleur F]]
[[Category: Munshi, P]]
[[Category: Munshi P]]
[[Category: Myles, D]]
[[Category: Myles D]]
[[Category: Isomerase]]
[[Category: Metalloenzyme]]
[[Category: Mutant enzyme]]
[[Category: Two metal binding site]]
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