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==Crystal structure of TR-alpha bound to T3 in a second site==
==Crystal structure of TR-alpha bound to T3 in a second site==
<StructureSection load='4lnw' size='340' side='right' caption='[[4lnw]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
<StructureSection load='4lnw' size='340' side='right'caption='[[4lnw]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4lnw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LNW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LNW FirstGlance]. <br>
<table><tr><td colspan='2'>[[4lnw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LNW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LNW FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=T3:3,5,3TRIIODOTHYRONINE'>T3</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CAS:S-(DIMETHYLARSENIC)CYSTEINE'>CAS</scene>, <scene name='pdbligand=T3:3,5,3TRIIODOTHYRONINE'>T3</scene></td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CAS:S-(DIMETHYLARSENIC)CYSTEINE'>CAS</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4lnw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lnw OCA], [https://pdbe.org/4lnw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4lnw RCSB], [https://www.ebi.ac.uk/pdbsum/4lnw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4lnw ProSAT]</span></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3ilz|3ilz]], [[3jzb|3jzb]], [[4lnx|4lnx]]</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">THRA, EAR7, ERBA1, NR1A1, THRA1, THRA2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4lnw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lnw OCA], [http://pdbe.org/4lnw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4lnw RCSB], [http://www.ebi.ac.uk/pdbsum/4lnw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4lnw ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
[[http://www.uniprot.org/uniprot/THA_HUMAN THA_HUMAN]] Defects in THRA are the cause of congenital hypothyroidism non-goitrous type 6 (CHNG6) [MIM:[http://omim.org/entry/614450 614450]]. A disease characterized by growth retardation, developmental retardation, skeletal dysplasia, borderline low thyroxine levels and high triiodothyronine levels. There is differential sensitivity to thyroid hormone action, with retention of hormone responsiveness in the hypothalamic pituitary axis and liver but skeletal, gastrointestinal, and myocardial resistance.<ref>PMID:22168587</ref>
[https://www.uniprot.org/uniprot/THA_HUMAN THA_HUMAN] Defects in THRA are the cause of congenital hypothyroidism non-goitrous type 6 (CHNG6) [MIM:[https://omim.org/entry/614450 614450]. A disease characterized by growth retardation, developmental retardation, skeletal dysplasia, borderline low thyroxine levels and high triiodothyronine levels. There is differential sensitivity to thyroid hormone action, with retention of hormone responsiveness in the hypothalamic pituitary axis and liver but skeletal, gastrointestinal, and myocardial resistance.<ref>PMID:22168587</ref>  
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/THA_HUMAN THA_HUMAN]] Nuclear hormone receptor. High affinity receptor for triiodothyronine.  
[https://www.uniprot.org/uniprot/THA_HUMAN THA_HUMAN] Nuclear hormone receptor. High affinity receptor for triiodothyronine.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4lnw" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4lnw" style="background-color:#fffaf0;"></div>
==See Also==
*[[Thyroid hormone receptor|Thyroid hormone receptor]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Aparicio, R]]
[[Category: Large Structures]]
[[Category: Polikarpov, I]]
[[Category: Aparicio R]]
[[Category: Puhl, A C]]
[[Category: Polikarpov I]]
[[Category: Mainly alpha orthogonal bundle]]
[[Category: Puhl AC]]
[[Category: Transcription]]
[[Category: Transcription factor]]
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