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==Crystal structure of human folate receptor alpha in complex with folic acid==
==Crystal structure of human folate receptor alpha in complex with folic acid==
<StructureSection load='4lrh' size='340' side='right' caption='[[4lrh]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
<StructureSection load='4lrh' size='340' side='right'caption='[[4lrh]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4lrh]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4keo 4keo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LRH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LRH FirstGlance]. <br>
<table><tr><td colspan='2'>[[4lrh]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4keo 4keo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LRH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LRH FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FOL:FOLIC+ACID'>FOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FOL:FOLIC+ACID'>FOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">FOLR1, FOLR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4lrh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lrh OCA], [https://pdbe.org/4lrh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4lrh RCSB], [https://www.ebi.ac.uk/pdbsum/4lrh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4lrh ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4lrh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lrh OCA], [http://pdbe.org/4lrh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4lrh RCSB], [http://www.ebi.ac.uk/pdbsum/4lrh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4lrh ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
[[http://www.uniprot.org/uniprot/FOLR1_HUMAN FOLR1_HUMAN]] Neurodegenerative syndrome due to cerebral folate transport deficiency. Neurodegeneration due to cerebral folate transport deficiency (NCFTD) [MIM:[http://omim.org/entry/613068 613068]]: A neurodegenerative disorder resulting from brain-specific folate deficiency early in life. Onset is apparent in late infancy with severe developmental regression, movement disturbances, epilepsy and leukodystrophy. Note=The disease is caused by mutations affecting the gene represented in this entry.  
[https://www.uniprot.org/uniprot/FOLR1_HUMAN FOLR1_HUMAN] Neurodegenerative syndrome due to cerebral folate transport deficiency. Neurodegeneration due to cerebral folate transport deficiency (NCFTD) [MIM:[https://omim.org/entry/613068 613068]: A neurodegenerative disorder resulting from brain-specific folate deficiency early in life. Onset is apparent in late infancy with severe developmental regression, movement disturbances, epilepsy and leukodystrophy. Note=The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/FOLR1_HUMAN FOLR1_HUMAN]] Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells.  
[https://www.uniprot.org/uniprot/FOLR1_HUMAN FOLR1_HUMAN] Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Brunzelle, J S]]
[[Category: Large Structures]]
[[Category: Chen, C]]
[[Category: Brunzelle JS]]
[[Category: Ke, J]]
[[Category: Chen C]]
[[Category: Li, J]]
[[Category: Ke J]]
[[Category: Melcher, K]]
[[Category: Li J]]
[[Category: Xu, H E]]
[[Category: Melcher K]]
[[Category: Yi, W]]
[[Category: Xu HE]]
[[Category: Young, E L]]
[[Category: Yi W]]
[[Category: Zhou, X E]]
[[Category: Young E-L]]
[[Category: Cysteine-rich glycoprotein]]
[[Category: Zhou XE]]
[[Category: Folate binding protein]]
[[Category: Folate receptor-alpha]]
[[Category: Folic acid]]
Retrieved from "https://proteopedia.org/4lrh"