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==Ternary complex between E. coli thymidylate synthase, dUMP, and F9==
==Ternary complex between E. coli thymidylate synthase, dUMP, and F9==
<StructureSection load='4lrr' size='340' side='right' caption='[[4lrr]], [[Resolution|resolution]] 2.41&Aring;' scene=''>
<StructureSection load='4lrr' size='340' side='right'caption='[[4lrr]], [[Resolution|resolution]] 2.41&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4lrr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Eco57 Eco57]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LRR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LRR FirstGlance]. <br>
<table><tr><td colspan='2'>[[4lrr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_O157:H7 Escherichia coli O157:H7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LRR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LRR FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CF9:2-OXO-2H-NAPHTHO[1,8-BC]FURAN-6-YL+4-NITROBENZOATE'>CF9</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=CF9:2-OXO-2H-NAPHTHO[1,8-BC]FURAN-6-YL+4-NITROBENZOATE'>CF9</scene>, <scene name='pdbligand=SCH:S-METHYL-THIO-CYSTEINE'>SCH</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=SCH:S-METHYL-THIO-CYSTEINE'>SCH</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4lrr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lrr OCA], [https://pdbe.org/4lrr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4lrr RCSB], [https://www.ebi.ac.uk/pdbsum/4lrr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4lrr ProSAT]</span></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4lrp|4lrp]]</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">thyA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83334 ECO57])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thymidylate_synthase Thymidylate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.45 2.1.1.45] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4lrr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lrr OCA], [http://pdbe.org/4lrr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4lrr RCSB], [http://www.ebi.ac.uk/pdbsum/4lrr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4lrr ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/TYSY_ECO57 TYSY_ECO57]] Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity).  
[https://www.uniprot.org/uniprot/TYSY_ECO57 TYSY_ECO57] Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
*[[Thymidylate synthase|Thymidylate synthase]]
*[[Thymidylate synthase 3D structures|Thymidylate synthase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Eco57]]
[[Category: Escherichia coli O157:H7]]
[[Category: Thymidylate synthase]]
[[Category: Large Structures]]
[[Category: Costi, M P]]
[[Category: Costi MP]]
[[Category: Ferrari, S]]
[[Category: Ferrari S]]
[[Category: Mangani, S]]
[[Category: Mangani S]]
[[Category: Pozzi, C]]
[[Category: Pozzi C]]
[[Category: Beta-mercaptoethanol modified cysteine]]
[[Category: N-terminal acetylated methionine]]
[[Category: Thymidine monophosphate synthesis]]
[[Category: Transferase]]

Revision as of 11:23, 14 December 2022

Ternary complex between E. coli thymidylate synthase, dUMP, and F9

4lrr, resolution 2.41Å

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