8bw3: Difference between revisions
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==PanDDA analysis -- Crystal Structure of PHIP in complex with Z198194396 synthetic derivative== | |||
<StructureSection load='8bw3' size='340' side='right'caption='[[8bw3]], [[Resolution|resolution]] 1.30Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8bw3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=5s9h 5s9h]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8BW3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8BW3 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=Y3V:(2S)-N-(cyclopropylmethyl)-2-methyl-4-(1-methyl-1H-pyrrole-2-carbonyl)piperazine-1-carboxamide'>Y3V</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8bw3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8bw3 OCA], [https://pdbe.org/8bw3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8bw3 RCSB], [https://www.ebi.ac.uk/pdbsum/8bw3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8bw3 ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/PHIP_HUMAN PHIP_HUMAN] Probable regulator of the insulin and insulin-like growth factor signaling pathways. Stimulates cell proliferation through regulation of cyclin transcription and has an anti-apoptotic activity through AKT1 phosphorylation and activation. Plays a role in the regulation of cell morphology and cytoskeletal organization.<ref>PMID:12242307</ref> <ref>PMID:21834987</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Aimon A]] | |||
[[Category: Biggin PC]] | |||
[[Category: Bradshaw WJ]] | |||
[[Category: Douangamath A]] | |||
[[Category: Grosjean H]] | |||
[[Category: Hassell-Hart S]] | |||
[[Category: Koekemoer L]] | |||
[[Category: Krojer T]] | |||
[[Category: Spencer J]] | |||
[[Category: Talon R]] | |||
[[Category: Von Delft F]] | |||
Revision as of 09:17, 21 December 2022
PanDDA analysis -- Crystal Structure of PHIP in complex with Z198194396 synthetic derivative
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