7x73: Difference between revisions

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'''Unreleased structure'''


The entry 7x73 is ON HOLD  until Paper Publication
==Structure of G9a in complex with RK-701==
 
<StructureSection load='7x73' size='340' side='right'caption='[[7x73]], [[Resolution|resolution]] 1.49&Aring;' scene=''>
Authors: Niwa, H., Shirai, F., Sato, S., Nishigaya, Y., Shirouzu, M., Umehara, T.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[7x73]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7X73 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7X73 FirstGlance]. <br>
Description: A structure of an enzyme in complex with compound 701
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=J26:N-[(2S)-1-[(4-cyanophenyl)amino]-4-cyclopropyl-1-oxidanylidene-butan-2-yl]-3,6,6-trimethyl-4-oxidanylidene-5,7-dihydro-1H-indole-2-carboxamide'>J26</scene>, <scene name='pdbligand=SFG:SINEFUNGIN'>SFG</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7x73 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7x73 OCA], [https://pdbe.org/7x73 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7x73 RCSB], [https://www.ebi.ac.uk/pdbsum/7x73 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7x73 ProSAT]</span></td></tr>
[[Category: Nishigaya, Y]]
</table>
[[Category: Shirouzu, M]]
== Function ==
[[Category: Shirai, F]]
[https://www.uniprot.org/uniprot/EHMT2_HUMAN EHMT2_HUMAN] Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also mediates monomethylation of 'Lys-56' of histone H3 (H3K56me1) in G1 phase, leading to promote interaction between histone H3 and PCNA and regulating DNA replication. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. May also methylate histone H1. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. Also methylates CDYL, WIZ, ACIN1, DNMT1, HDAC1, ERCC6, KLF12 and itself.<ref>PMID:8457211</ref> <ref>PMID:11316813</ref> <ref>PMID:18438403</ref> <ref>PMID:20118233</ref> <ref>PMID:22387026</ref>
[[Category: Niwa, H]]
== References ==
[[Category: Sato, S]]
<references/>
[[Category: Umehara, T]]
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Nishigaya Y]]
[[Category: Niwa H]]
[[Category: Sato S]]
[[Category: Shirai F]]
[[Category: Shirouzu M]]
[[Category: Umehara T]]
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