8bbh: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry 8bbh is ON HOLD~~

==The crystal structure of a mouse Fab fragment TL1 in complex with a human Glucose-6-phosphate isomerase peptide 293-307==

~~Authors: Changrong, G., Rikard, H., Taotao, L.~~

== Structural highlights ==

<table><tr><td colspan='2'>[[8bbh]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8BBH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8BBH FirstGlance]. <br>

~~Description:~~ The crystal structure of a mouse Fab fragment TL1 in complex with a human Glucose-6-phosphate isomerase peptide 293-307

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACA:6-AMINOHEXANOIC+ACID'>ACA</scene></td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8bbh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8bbh OCA], [https://pdbe.org/8bbh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8bbh RCSB], [https://www.ebi.ac.uk/pdbsum/8bbh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8bbh ProSAT]</span></td></tr>

[[Category: Changrong, G]]

</table>

[[Category: Rikard, H]]

== Disease ==

[[Category: Taotao, L]]

[https://www.uniprot.org/uniprot/G6PI_HUMAN G6PI_HUMAN] Defects in GPI are the cause of hemolytic anemia non-spherocytic due to glucose phosphate isomerase deficiency (HA-GPID) [MIM:[https://omim.org/entry/613470 613470]. It is a form of anemia in which there is no abnormal hemoglobin or spherocytosis. It is caused by glucose phosphate isomerase deficiency. Severe GPI deficiency can be associated with hydrops fetalis, immediate neonatal death and neurological impairment.

== Function ==

[https://www.uniprot.org/uniprot/G6PI_HUMAN G6PI_HUMAN] Besides it's role as a glycolytic enzyme, mammalian GPI can function as a tumor-secreted cytokine and an angiogenic factor (AMF) that stimulates endothelial cell motility. GPI is also a neurotrophic factor (Neuroleukin) for spinal and sensory neurons.<ref>PMID:11004567</ref> <ref>PMID:11437381</ref> <ref>PMID:12163179</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Mus musculus]]

[[Category: Changrong G]]

[[Category: Rikard H]]

[[Category: Taotao L]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 8bbh is ON HOLD
+==The crystal structure of a mouse Fab fragment TL1 in complex with a human Glucose-6-phosphate isomerase peptide 293-307==
+<StructureSection load='8bbh' size='340' side='right'caption='[[8bbh]], [[Resolution|resolution]] 1.62&Aring;' scene=''>
-Authors: Changrong, G., Rikard, H., Taotao, L.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[8bbh]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8BBH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8BBH FirstGlance]. <br>
-Description: The crystal structure of a mouse Fab fragment TL1 in complex with a human Glucose-6-phosphate isomerase peptide 293-307
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACA:6-AMINOHEXANOIC+ACID'>ACA</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8bbh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8bbh OCA], [https://pdbe.org/8bbh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8bbh RCSB], [https://www.ebi.ac.uk/pdbsum/8bbh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8bbh ProSAT]</span></td></tr>
-[[Category: Changrong, G]]
+</table>
-[[Category: Rikard, H]]
+== Disease ==
-[[Category: Taotao, L]]
+[https://www.uniprot.org/uniprot/G6PI_HUMAN G6PI_HUMAN] Defects in GPI are the cause of hemolytic anemia non-spherocytic due to glucose phosphate isomerase deficiency (HA-GPID) [MIM:[https://omim.org/entry/613470 613470]. It is a form of anemia in which there is no abnormal hemoglobin or spherocytosis. It is caused by glucose phosphate isomerase deficiency. Severe GPI deficiency can be associated with hydrops fetalis, immediate neonatal death and neurological impairment.
+== Function ==
+[https://www.uniprot.org/uniprot/G6PI_HUMAN G6PI_HUMAN] Besides it's role as a glycolytic enzyme, mammalian GPI can function as a tumor-secreted cytokine and an angiogenic factor (AMF) that stimulates endothelial cell motility. GPI is also a neurotrophic factor (Neuroleukin) for spinal and sensory neurons.<ref>PMID:11004567</ref> <ref>PMID:11437381</ref> <ref>PMID:12163179</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Mus musculus]]
+[[Category: Changrong G]]
+[[Category: Rikard H]]
+[[Category: Taotao L]]