1ds6: Difference between revisions

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== Structural highlights ==

<table><tr><td colspan='2'>[[1ds6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DS6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DS6 FirstGlance]. <br>

<table><tr><td colspan='2'>[[1ds6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DS6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DS6 FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ds6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ds6 OCA], [https://pdbe.org/1ds6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ds6 RCSB], [https://www.ebi.ac.uk/pdbsum/1ds6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ds6 ProSAT]</span></td></tr>

</table>

== Disease ==

[[https://www.uniprot.org/uniprot/RAC2_HUMAN RAC2_HUMAN]] Defects in RAC2 are the cause of neutrophil immunodeficiency syndrome (NEUID) [MIM:[https://omim.org/entry/608203 608203]].<ref>PMID:10758162</ref>

[https://www.uniprot.org/uniprot/RAC2_HUMAN RAC2_HUMAN] Defects in RAC2 are the cause of neutrophil immunodeficiency syndrome (NEUID) [MIM:[https://omim.org/entry/608203 608203].<ref>PMID:10758162</ref>

== Function ==

[[https://www.uniprot.org/uniprot/RAC2_HUMAN RAC2_HUMAN]] Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. Augments the production of reactive oxygen species (ROS) by NADPH oxidase.<ref>PMID:1660188</ref> [[https://www.uniprot.org/uniprot/GDIR2_HUMAN GDIR2_HUMAN]] Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them.

[https://www.uniprot.org/uniprot/RAC2_HUMAN RAC2_HUMAN] Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. Augments the production of reactive oxygen species (ROS) by NADPH oxidase.<ref>PMID:1660188</ref>

== Evolutionary Conservation ==

[[Image:Consurf_key_small.gif|200px|right]]

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__TOC__

</StructureSection>

[[Category: ~~Human~~]]

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Gierschik, P]]

[[Category: Gierschik P]]

[[Category: Illenberger, D]]

[[Category: Illenberger D]]

[[Category: Jensen~~, O N~~]]

[[Category: Jensen ON]]

[[Category: Scheffzek, K]]

[[Category: Scheffzek K]]

[[Category: Stephan, I]]

[[Category: Stephan I]]

~~[[Category: Beta sandwhich]]~~

~~[[Category: G-domain]]~~

~~[[Category: Gtp-binding protein]]~~

~~[[Category: Immunoglobulin fold]]~~

~~[[Category: Protein-protein complex]]~~

~~[[Category: Signaling protein]]~~

~~[[Category: Walker fold~~]]

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@@ Line 3: / Line 3: @@
 <StructureSection load='1ds6' size='340' side='right'caption='[[1ds6]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1ds6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DS6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DS6 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1ds6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DS6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DS6 FirstGlance]. <br>
 </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
 <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ds6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ds6 OCA], [https://pdbe.org/1ds6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ds6 RCSB], [https://www.ebi.ac.uk/pdbsum/1ds6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ds6 ProSAT]</span></td></tr>
 </table>
 == Disease ==
-[[https://www.uniprot.org/uniprot/RAC2_HUMAN RAC2_HUMAN]] Defects in RAC2 are the cause of neutrophil immunodeficiency syndrome (NEUID) [MIM:[https://omim.org/entry/608203 608203]].<ref>PMID:10758162</ref>
+[https://www.uniprot.org/uniprot/RAC2_HUMAN RAC2_HUMAN] Defects in RAC2 are the cause of neutrophil immunodeficiency syndrome (NEUID) [MIM:[https://omim.org/entry/608203 608203].<ref>PMID:10758162</ref>
 == Function ==
-[[https://www.uniprot.org/uniprot/RAC2_HUMAN RAC2_HUMAN]] Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. Augments the production of reactive oxygen species (ROS) by NADPH oxidase.<ref>PMID:1660188</ref>  [[https://www.uniprot.org/uniprot/GDIR2_HUMAN GDIR2_HUMAN]] Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them.
+[https://www.uniprot.org/uniprot/RAC2_HUMAN RAC2_HUMAN] Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. Augments the production of reactive oxygen species (ROS) by NADPH oxidase.<ref>PMID:1660188</ref>
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 37: / Line 37: @@
 __TOC__
 </StructureSection>
-[[Category: Human]]
+[[Category: Homo sapiens]]
 [[Category: Large Structures]]
-[[Category: Gierschik, P]]
+[[Category: Gierschik P]]
-[[Category: Illenberger, D]]
+[[Category: Illenberger D]]
-[[Category: Jensen, O N]]
+[[Category: Jensen ON]]
-[[Category: Scheffzek, K]]
+[[Category: Scheffzek K]]
-[[Category: Stephan, I]]
+[[Category: Stephan I]]
-[[Category: Beta sandwhich]]
-[[Category: G-domain]]
-[[Category: Gtp-binding protein]]
-[[Category: Immunoglobulin fold]]
-[[Category: Protein-protein complex]]
-[[Category: Signaling protein]]
-[[Category: Walker fold]]