1nd7: Difference between revisions

<table><tr><td colspan='2'>[[1nd7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ND7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ND7 FirstGlance]. <br>

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nd7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nd7 OCA], [https://pdbe.org/1nd7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nd7 RCSB], [https://www.ebi.ac.uk/pdbsum/1nd7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nd7 ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/WWP1_HUMAN WWP1_HUMAN] E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. Ubiquitinates RNF11 without targeting it for degradation. Ubiquitinates and promotes degradation of TGFBR1; the ubiquitination is enhanced by SMAD7. Ubiquitinates SMAD6 and SMAD7. Ubiquitinates and promotes degradation of SMAD2 in response to TGF-beta signaling, which requires interaction with TGIF.<ref>PMID:15359284</ref> <ref>PMID:15221015</ref> <ref>PMID:12535537</ref>  

[[Category: Homo sapiens]]

[[Category: Bowman ME]]

[[Category: Ferrer J-L]]

[[Category: Hunter T]]

[[Category: Joaziero CAP]]

[[Category: Noel JP]]

[[Category: Verdecia MA]]

[[Category: Wells NJ]]