7aw8

Alpha-actinin in Rhodamnia argentea

spinqualitylabelsall models 7aw8, resolution 1.50Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 7aw8 is a 1 chain structure with sequence from Rhodamnia argentea. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: ACY, FMT Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed The Australian tree malletwood (Rhodamnia argentea) is unique. The genome of malletwood is the only known plant genome that contains a gene coding for an alpha-actinin-like protein. Several organisms predating the animal-plant bifurcation express an alpha-actinin or alpha-actinin-like protein. Therefore, it appears that plants in general, but not malletwood, have lost the alpha-actinin or alpha-actinin-like gene during evolution. In order to characterize its structure and function, we synthesized the gene and expressed the recombinant R. argentea protein. The results clearly show that this protein has all properties of genuine alpha-actinin. The N-terminal actin-binding domain (ABD), with two calponin homology motifs, is very similar to the ABD of any alpha-actinin. The C-terminal calmodulin-like domain, as well as the intervening rod domain, are also similar to the corresponding regions in other alpha-actinins. The R. argentea alpha-actinin-like protein dimerises in solution and thereby can cross-link actin filaments. Based on these results, we believe the R. argentea protein represents a genuine alpha-actinin, making R. argentea unique in the plant world. Structural and functional characterization of a plant alpha-actinin.,Persson K, Backman L FEBS Open Bio. 2021 Jun 10. doi: 10.1002/2211-5463.13222. PMID:34110107 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Actinin 3D structures

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