4luq: Difference between revisions

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==Crystal structure of virulence effector Tse3 in complex with neutralizer Tsi3==
==Crystal structure of virulence effector Tse3 in complex with neutralizer Tsi3==
<StructureSection load='4luq' size='340' side='right' caption='[[4luq]], [[Resolution|resolution]] 1.77&Aring;' scene=''>
<StructureSection load='4luq' size='340' side='right'caption='[[4luq]], [[Resolution|resolution]] 1.77&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4luq]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseae Pseae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LUQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LUQ FirstGlance]. <br>
<table><tr><td colspan='2'>[[4luq]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LUQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LUQ FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PA3484 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=208964 PSEAE]), PA3485 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=208964 PSEAE])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4luq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4luq OCA], [https://pdbe.org/4luq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4luq RCSB], [https://www.ebi.ac.uk/pdbsum/4luq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4luq ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4luq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4luq OCA], [http://pdbe.org/4luq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4luq RCSB], [http://www.ebi.ac.uk/pdbsum/4luq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4luq ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TSE3_PSEAE TSE3_PSEAE] Toxin secreted by the H1 type VI (H1-T6SS) secretion system into the periplasm of recipient cells. Degrades peptidoglycan via muramidase activity thereby helping itself to compete with other bacteria (PubMed:21776080). To protect itself, the bacterium synthesizes immunity protein Tsi3 that specifically interacts with and inactivates cognate toxin (PubMed:24025333).<ref>PMID:21776080</ref> <ref>PMID:24025333</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Pseae]]
[[Category: Large Structures]]
[[Category: Li, L]]
[[Category: Pseudomonas aeruginosa PAO1]]
[[Category: Wang, T]]
[[Category: Li L]]
[[Category: Zhang, W]]
[[Category: Wang T]]
[[Category: Arm]]
[[Category: Zhang W]]
[[Category: Catalytic domain]]
[[Category: Goose type lysozyme]]
[[Category: Heat like motif]]
[[Category: Muramidase]]
[[Category: Protein binding-toxin inhibitor complex]]
[[Category: Tsi3]]
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