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==Crystal structure of the mouse RIP3 kinase domain==
==Crystal structure of the mouse RIP3 kinase domain==
<StructureSection load='4m66' size='340' side='right' caption='[[4m66]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
<StructureSection load='4m66' size='340' side='right'caption='[[4m66]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4m66]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M66 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4M66 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4m66]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M66 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4M66 FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4m67|4m67]], [[4m68|4m68]], [[4m69|4m69]]</td></tr>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4m66 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m66 OCA], [https://pdbe.org/4m66 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4m66 RCSB], [https://www.ebi.ac.uk/pdbsum/4m66 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4m66 ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Ripk3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4m66 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m66 OCA], [http://pdbe.org/4m66 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4m66 RCSB], [http://www.ebi.ac.uk/pdbsum/4m66 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4m66 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/RIPK3_MOUSE RIPK3_MOUSE]] Essential for programmed necrosis in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production (By similarity).<ref>PMID:19590578</ref>
[https://www.uniprot.org/uniprot/RIPK3_MOUSE RIPK3_MOUSE] Essential for programmed necrosis in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production (By similarity).<ref>PMID:19590578</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Lk3 transgenic mice]]
[[Category: Large Structures]]
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Mus musculus]]
[[Category: Peng, W]]
[[Category: Peng W]]
[[Category: Shi, Y]]
[[Category: Shi Y]]
[[Category: Wu, J]]
[[Category: Wu J]]
[[Category: Xie, T]]
[[Category: Xie T]]
[[Category: Yan, C]]
[[Category: Yan C]]
[[Category: Kinase]]
[[Category: Protein phosphorylation]]
[[Category: Transferase]]
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