4mf3: Difference between revisions
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==Crystal Structure of Human GRIK1 complexed with a 6-(tetrazolyl)aryl decahydroisoquinoline antagonist== | ==Crystal Structure of Human GRIK1 complexed with a 6-(tetrazolyl)aryl decahydroisoquinoline antagonist== | ||
<StructureSection load='4mf3' size='340' side='right' caption='[[4mf3]], [[Resolution|resolution]] 3.00Å' scene=''> | <StructureSection load='4mf3' size='340' side='right'caption='[[4mf3]], [[Resolution|resolution]] 3.00Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4mf3]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[4mf3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MF3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MF3 FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SXI:(3S,4AS,6S,8AR)-6-[3-CHLORO-2-(1H-TETRAZOL-5-YL)PHENOXY]DECAHYDROISOQUINOLINE-3-CARBOXYLIC+ACID'>SXI</scene> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SXI:(3S,4AS,6S,8AR)-6-[3-CHLORO-2-(1H-TETRAZOL-5-YL)PHENOXY]DECAHYDROISOQUINOLINE-3-CARBOXYLIC+ACID'>SXI</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mf3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mf3 OCA], [https://pdbe.org/4mf3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mf3 RCSB], [https://www.ebi.ac.uk/pdbsum/4mf3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mf3 ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/GRIK1_HUMAN GRIK1_HUMAN] Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus. | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 19: | Line 18: | ||
</div> | </div> | ||
<div class="pdbe-citations 4mf3" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 4mf3" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[Glutamate receptor 3D structures|Glutamate receptor 3D structures]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Alt | [[Category: Large Structures]] | ||
[[Category: Arnold | [[Category: Alt A]] | ||
[[Category: Bell | [[Category: Arnold BM]] | ||
[[Category: Bleakman | [[Category: Bell MG]] | ||
[[Category: Bleisch | [[Category: Bleakman D]] | ||
[[Category: Castano | [[Category: Bleisch TJ]] | ||
[[Category: Clawson | [[Category: Castano AM]] | ||
[[Category: Dominguez | [[Category: Clawson DK]] | ||
[[Category: Escribano | [[Category: Del Prado M]] | ||
[[Category: Filla | [[Category: Dominguez E]] | ||
[[Category: Ho | [[Category: Escribano AM]] | ||
[[Category: Hudziak | [[Category: Filla SA]] | ||
[[Category: Iyengar | [[Category: Ho KH]] | ||
[[Category: Jones | [[Category: Hudziak KJ]] | ||
[[Category: Katofiasc | [[Category: Iyengar S]] | ||
[[Category: Martinez-Perez | [[Category: Jones CK]] | ||
[[Category: Mateo | [[Category: Katofiasc MA]] | ||
[[Category: Mathes | [[Category: Martinez-Perez JA]] | ||
[[Category: Mattiuz | [[Category: Mateo A]] | ||
[[Category: Ogden | [[Category: Mathes BM]] | ||
[[Category: Ornstein | [[Category: Mattiuz EL]] | ||
[[Category: Phebus | [[Category: Ogden AML]] | ||
[[Category: Ornstein PL]] | |||
[[Category: Shannon | [[Category: Phebus LA]] | ||
[[Category: Simmons | [[Category: Shannon HE]] | ||
[[Category: Stack | [[Category: Simmons RMA]] | ||
[[Category: Stratford | [[Category: Stack DR]] | ||
[[Category: Winter | [[Category: Stratford RE]] | ||
[[Category: Wu | [[Category: Winter MA]] | ||
[[Category: Wu Z]] | |||
Revision as of 11:13, 21 December 2022
Crystal Structure of Human GRIK1 complexed with a 6-(tetrazolyl)aryl decahydroisoquinoline antagonist
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Proteopedia Page Contributors and Editors (what is this?)
Categories:
- Homo sapiens
- Large Structures
- Alt A
- Arnold BM
- Bell MG
- Bleakman D
- Bleisch TJ
- Castano AM
- Clawson DK
- Del Prado M
- Dominguez E
- Escribano AM
- Filla SA
- Ho KH
- Hudziak KJ
- Iyengar S
- Jones CK
- Katofiasc MA
- Martinez-Perez JA
- Mateo A
- Mathes BM
- Mattiuz EL
- Ogden AML
- Ornstein PL
- Phebus LA
- Shannon HE
- Simmons RMA
- Stack DR
- Stratford RE
- Winter MA
- Wu Z
