7ox2: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 7ox2 is ~~ON HOLD until Paper Publication~~

==Fab 6E2: hIL-9 complex==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[7ox2]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7OX2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7OX2 FirstGlance]. <br>

~~Description~~:

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ox2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ox2 OCA], [https://pdbe.org/7ox2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ox2 RCSB], [https://www.ebi.ac.uk/pdbsum/7ox2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ox2 ProSAT]</span></td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/IL9_HUMAN IL9_HUMAN] Multifunctional cytokine secreted mainly by T-helper 2 lymphocytes and also mast cells or NKT cells that plays important roles in the immune response against parasites (PubMed:29742432). Affects intestinal epithelial permeability and adaptive immunity (PubMed:29742432). In addition, induces the differentiation of specific T-cell subsets such as IL-17 producing helper T-cells (TH17) and also proliferation and differentiation of mast cells. Mechanistically, exerts its biological effects through a receptor composed of IL9R subunit and a signal transducing subunit IL2RG. Receptor stimulation results in the rapid activation of JAK1 and JAK3 kinase activities leading to STAT1, STAT3 and STAT5-mediated transcriptional programs. Induction of differentiation genes seems to be mediated by STAT1 alone, while protection of cells from apoptosis depends on STAT3 and STAT5.[UniProtKB:P15247]<ref>PMID:29742432</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: De Vos T]]

[[Category: Savvides SN]]

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 7ox2 is ON HOLD  until Paper Publication
+==Fab 6E2: hIL-9 complex==
+<StructureSection load='7ox2' size='340' side='right'caption='[[7ox2]], [[Resolution|resolution]] 3.34&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[7ox2]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7OX2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7OX2 FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ox2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ox2 OCA], [https://pdbe.org/7ox2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ox2 RCSB], [https://www.ebi.ac.uk/pdbsum/7ox2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ox2 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/IL9_HUMAN IL9_HUMAN] Multifunctional cytokine secreted mainly by T-helper 2 lymphocytes and also mast cells or NKT cells that plays important roles in the immune response against parasites (PubMed:29742432). Affects intestinal epithelial permeability and adaptive immunity (PubMed:29742432). In addition, induces the differentiation of specific T-cell subsets such as IL-17 producing helper T-cells (TH17) and also proliferation and differentiation of mast cells. Mechanistically, exerts its biological effects through a receptor composed of IL9R subunit and a signal transducing subunit IL2RG. Receptor stimulation results in the rapid activation of JAK1 and JAK3 kinase activities leading to STAT1, STAT3 and STAT5-mediated transcriptional programs. Induction of differentiation genes seems to be mediated by STAT1 alone, while protection of cells from apoptosis depends on STAT3 and STAT5.[UniProtKB:P15247]<ref>PMID:29742432</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: De Vos T]]
+[[Category: Savvides SN]]