7zir: Difference between revisions

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'''Unreleased structure'''


The entry 7zir is ON HOLD  until Paper Publication
==Cryo-EM structure of hnRNPDL amyloid fibrils==
 
<StructureSection load='7zir' size='340' side='right'caption='[[7zir]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
Authors:  
== Structural highlights ==
 
<table><tr><td colspan='2'>[[7zir]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZIR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZIR FirstGlance]. <br>
Description:  
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zir FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zir OCA], [https://pdbe.org/7zir PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zir RCSB], [https://www.ebi.ac.uk/pdbsum/7zir PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zir ProSAT]</span></td></tr>
[[Category: Unreleased Structures]]
</table>
== Disease ==
[https://www.uniprot.org/uniprot/HNRDL_HUMAN HNRDL_HUMAN] HNRNPDL-related limb-girdle muscular dystrophy D3. The disease is caused by variants affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/HNRDL_HUMAN HNRDL_HUMAN] Acts as a transcriptional regulator. Promotes transcription repression. Promotes transcription activation in differentiated myotubes (By similarity). Binds to double- and single-stranded DNA sequences. Binds to the transcription suppressor CATR sequence of the COX5B promoter (By similarity). Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs. Binds both to nuclear and cytoplasmic poly(A) mRNAs. Binds to poly(G) and poly(A), but not to poly(U) or poly(C) RNA homopolymers. Binds to the 5'-ACUAGC-3' RNA consensus sequence.<ref>PMID:9538234</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Bartolome-Nafria A]]
[[Category: Bolognesi M]]
[[Category: Chaves-Sanjuan A]]
[[Category: Garcia-Pardo J]]
[[Category: Gil-Garcia M]]
[[Category: Ricagno S]]
[[Category: Ventura S]]
[[Category: Visentin C]]
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