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==Crystal structure of apo-form of glutaminyl cyclase from Ixodes scapularis==
==Crystal structure of apo-form of glutaminyl cyclase from Ixodes scapularis==
<StructureSection load='4mhp' size='340' side='right' caption='[[4mhp]], [[Resolution|resolution]] 1.10&Aring;' scene=''>
<StructureSection load='4mhp' size='340' side='right'caption='[[4mhp]], [[Resolution|resolution]] 1.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4mhp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Black-legged_tick Black-legged tick]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MHP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MHP FirstGlance]. <br>
<table><tr><td colspan='2'>[[4mhp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Ixodes_scapularis Ixodes scapularis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MHP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MHP FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4mhn|4mhn]], [[4mhy|4mhy]], [[4mhz|4mhz]]</td></tr>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mhp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mhp OCA], [https://pdbe.org/4mhp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mhp RCSB], [https://www.ebi.ac.uk/pdbsum/4mhp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mhp ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">IscW_ISCW023264 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6945 Black-legged tick])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutaminyl-peptide_cyclotransferase Glutaminyl-peptide cyclotransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.2.5 2.3.2.5] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mhp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mhp OCA], [http://pdbe.org/4mhp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4mhp RCSB], [http://www.ebi.ac.uk/pdbsum/4mhp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4mhp ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/QPCT_IXOSC QPCT_IXOSC] Responsible for the biosynthesis of pyroglutamyl peptides (PubMed:23770496, PubMed:24598748). Seems to have a preference for substrates with neutral or hydrophobic amino-acid residues at the second and third positions (PubMed:24598748). Shows activity towards the peptides [Gln-1]-corazonin, [Gln-1]-periviscerokinin and [Gln-1]-sulfakinin (PubMed:24598748).<ref>PMID:23770496</ref> <ref>PMID:24598748</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Black-legged tick]]
[[Category: Ixodes scapularis]]
[[Category: Glutaminyl-peptide cyclotransferase]]
[[Category: Large Structures]]
[[Category: Hsu, H L]]
[[Category: Hsu HL]]
[[Category: Huang, K F]]
[[Category: Huang KF]]
[[Category: Wang, A H.J]]
[[Category: Wang AHJ]]
[[Category: Alpha/beta-mixed fold]]
[[Category: Glutaminyl cyclase]]
[[Category: Secreted protein]]
[[Category: Transferase]]
Retrieved from "https://proteopedia.org/4mhp"