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==Crystal structure of heparan sulfate lyase HepC mutant from Pedobacter heparinus==
==Crystal structure of heparan sulfate lyase HepC mutant from Pedobacter heparinus==
<StructureSection load='4mmi' size='340' side='right' caption='[[4mmi]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
<StructureSection load='4mmi' size='340' side='right'caption='[[4mmi]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4mmi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_13125 Atcc 13125]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MMI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MMI FirstGlance]. <br>
<table><tr><td colspan='2'>[[4mmi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pedobacter_heparinus Pedobacter heparinus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MMI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MMI FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4mmh|4mmh]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mmi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mmi OCA], [https://pdbe.org/4mmi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mmi RCSB], [https://www.ebi.ac.uk/pdbsum/4mmi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mmi ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HepC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=984 ATCC 13125])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Heparin-sulfate_lyase Heparin-sulfate lyase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.2.8 4.2.2.8] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mmi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mmi OCA], [http://pdbe.org/4mmi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4mmi RCSB], [http://www.ebi.ac.uk/pdbsum/4mmi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4mmi ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/HEPC_PEDHD HEPC_PEDHD]] Specifically cleaves heparan sulfate-rich regions of acidic polysaccharides. Does not act on N,O-desulfated glucosamine or N-acetyl-O-sulfated glucosamine linkages. Functions in cleaving metazoan heparan sulfate and providing carbon, nitrogen and sulfate sources for microorganisms.<ref>PMID:8702264</ref> <ref>PMID:10747789</ref>
[https://www.uniprot.org/uniprot/HEPC_PEDHD HEPC_PEDHD] Specifically cleaves heparan sulfate-rich regions of acidic polysaccharides. Does not act on N,O-desulfated glucosamine or N-acetyl-O-sulfated glucosamine linkages. Functions in cleaving metazoan heparan sulfate and providing carbon, nitrogen and sulfate sources for microorganisms.<ref>PMID:8702264</ref> <ref>PMID:10747789</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Atcc 13125]]
[[Category: Large Structures]]
[[Category: Heparin-sulfate lyase]]
[[Category: Pedobacter heparinus]]
[[Category: Hashimoto, W]]
[[Category: Hashimoto W]]
[[Category: Maruyama, Y]]
[[Category: Maruyama Y]]
[[Category: Mikami, B]]
[[Category: Mikami B]]
[[Category: Murata, K]]
[[Category: Murata K]]
[[Category: Nakamichi, Y]]
[[Category: Nakamichi Y]]
[[Category: Alpha/alpha barrel anti-parallel beta-sheet]]
[[Category: Heparinase]]
[[Category: Lyase]]
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