4mn3: Difference between revisions
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==Chromodomain antagonists that target the polycomb-group methyllysine reader protein Chromobox homolog 7 (CBX7)== | ==Chromodomain antagonists that target the polycomb-group methyllysine reader protein Chromobox homolog 7 (CBX7)== | ||
<StructureSection load='4mn3' size='340' side='right' caption='[[4mn3]], [[Resolution|resolution]] 1.54Å' scene=''> | <StructureSection load='4mn3' size='340' side='right'caption='[[4mn3]], [[Resolution|resolution]] 1.54Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4mn3]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[4mn3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MN3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MN3 FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=M3L:N-TRIMETHYLLYSINE'>M3L</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=P33:3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL'>P33</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mn3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mn3 OCA], [https://pdbe.org/4mn3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mn3 RCSB], [https://www.ebi.ac.uk/pdbsum/4mn3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mn3 ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/CBX7_HUMAN CBX7_HUMAN] Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Promotes histone H3 trimethylation at 'Lys-9' (H3K9me3). Binds to trimethylated lysine residues in histones, and possibly also other proteins. Regulator of cellular lifespan by maintaining the repression of CDKN2A, but not by inducing telomerase activity.<ref>PMID:19636380</ref> <ref>PMID:21060834</ref> <ref>PMID:21282530</ref> <ref>PMID:21047797</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Boulanger | [[Category: Large Structures]] | ||
[[Category: Chakravarthi | [[Category: Synthetic construct]] | ||
[[Category: Daze | [[Category: Boulanger MJ]] | ||
[[Category: Dev | [[Category: Chakravarthi S]] | ||
[[Category: Douglas | [[Category: Daze K]] | ||
[[Category: Heller | [[Category: Dev A]] | ||
[[Category: Hof | [[Category: Douglas S]] | ||
[[Category: Peng | [[Category: Heller M]] | ||
[[Category: Quon | [[Category: Hof F]] | ||
[[Category: Wulff | [[Category: Peng F]] | ||
[[Category: Quon T]] | |||
[[Category: Wulff J]] | |||
Revision as of 09:51, 28 December 2022
Chromodomain antagonists that target the polycomb-group methyllysine reader protein Chromobox homolog 7 (CBX7)
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