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==Wild-type human neuroglobin==
==Wild-type human neuroglobin==
<StructureSection load='4mpm' size='340' side='right' caption='[[4mpm]], [[Resolution|resolution]] 1.74&Aring;' scene=''>
<StructureSection load='4mpm' size='340' side='right'caption='[[4mpm]], [[Resolution|resolution]] 1.74&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4mpm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MPM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MPM FirstGlance]. <br>
<table><tr><td colspan='2'>[[4mpm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MPM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MPM FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1oj6|1oj6]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mpm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mpm OCA], [https://pdbe.org/4mpm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mpm RCSB], [https://www.ebi.ac.uk/pdbsum/4mpm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mpm ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NGB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mpm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mpm OCA], [http://pdbe.org/4mpm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4mpm RCSB], [http://www.ebi.ac.uk/pdbsum/4mpm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4mpm ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/NGB_HUMAN NGB_HUMAN]] Involved in oxygen transport in the brain. Hexacoordinate globin, displaying competitive binding of oxygen or the distal His residue to the iron atom. Not capable of penetrating cell membranes. The deoxygenated form exhibits nitrite reductase activity inhibiting cellular respiration via NO-binding to cytochrome c oxidase. Involved in neuroprotection during oxidative stress. May exert its anti-apoptotic activity by acting to reset the trigger level of mitochondrial cytochrome c release necessary to commit the cells to apoptosis.<ref>PMID:11029004</ref> <ref>PMID:11473128</ref> <ref>PMID:18416560</ref> <ref>PMID:21190290</ref> <ref>PMID:21296891</ref>
[https://www.uniprot.org/uniprot/NGB_HUMAN NGB_HUMAN] Involved in oxygen transport in the brain. Hexacoordinate globin, displaying competitive binding of oxygen or the distal His residue to the iron atom. Not capable of penetrating cell membranes. The deoxygenated form exhibits nitrite reductase activity inhibiting cellular respiration via NO-binding to cytochrome c oxidase. Involved in neuroprotection during oxidative stress. May exert its anti-apoptotic activity by acting to reset the trigger level of mitochondrial cytochrome c release necessary to commit the cells to apoptosis.<ref>PMID:11029004</ref> <ref>PMID:11473128</ref> <ref>PMID:18416560</ref> <ref>PMID:21190290</ref> <ref>PMID:21296891</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Golinelli-Pimpaneau, B]]
[[Category: Large Structures]]
[[Category: Guimaraes, B G]]
[[Category: Golinelli-Pimpaneau B]]
[[Category: Apoptosis]]
[[Category: Guimaraes BG]]
[[Category: Brain neuron]]
[[Category: Globin]]
[[Category: Nitrite reductase]]
[[Category: Oxygen supply]]
[[Category: Proto-porphyrin ix]]

Revision as of 10:00, 28 December 2022

Wild-type human neuroglobin

4mpm, resolution 1.74Å

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