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==Structure of the Phosphopantetheine Transferase Sfp in Complex with Coenzyme A and a Peptidyl Carrier Protein==
==Structure of the Phosphopantetheine Transferase Sfp in Complex with Coenzyme A and a Peptidyl Carrier Protein==
<StructureSection load='4mrt' size='340' side='right' caption='[[4mrt]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='4mrt' size='340' side='right'caption='[[4mrt]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4mrt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_10027 Atcc 10027] and [http://en.wikipedia.org/wiki/Bacsu Bacsu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MRT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MRT FirstGlance]. <br>
<table><tr><td colspan='2'>[[4mrt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis_subsp._subtilis_str._168 Bacillus subtilis subsp. subtilis str. 168] and [https://en.wikipedia.org/wiki/Brevibacillus_parabrevis Brevibacillus parabrevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MRT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MRT FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2md9|2md9]], [[1qr0|1qr0]], [[2ge1|2ge1]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mrt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mrt OCA], [https://pdbe.org/4mrt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mrt RCSB], [https://www.ebi.ac.uk/pdbsum/4mrt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mrt ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">tycC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=54914 ATCC 10027]), BSU03570, lpa-8, sfp ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=224308 BACSU])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mrt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mrt OCA], [http://pdbe.org/4mrt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4mrt RCSB], [http://www.ebi.ac.uk/pdbsum/4mrt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4mrt ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/TYCC_BREPA TYCC_BREPA]] Incorporates six amino acids (for tyrocidine A, Asn, Gln, Tyr, Val, Orn, and Leu) in their L-configuration into the peptide product. [[http://www.uniprot.org/uniprot/SFP_BACSU SFP_BACSU]] Activates the seven peptidyl carrier protein (PCP) domains of surfactin synthase SRF1/2/3 by transferring the 4'-phosphopantetheinyl moiety of coenzyme A (CoA) to a serine residue. Required for cells of B.subtilis to become producers of the lipopeptide antibiotics surfactin and plipastatin B1.<ref>PMID:8939709</ref> 
[https://www.uniprot.org/uniprot/TYCC_BREPA TYCC_BREPA] Incorporates six amino acids (for tyrocidine A, Asn, Gln, Tyr, Val, Orn, and Leu) in their L-configuration into the peptide product.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Atcc 10027]]
[[Category: Bacillus subtilis subsp. subtilis str. 168]]
[[Category: Bacsu]]
[[Category: Brevibacillus parabrevis]]
[[Category: Dikic, I]]
[[Category: Large Structures]]
[[Category: Doetsch, V]]
[[Category: Dikic I]]
[[Category: Guentert, P]]
[[Category: Doetsch V]]
[[Category: Henrich, E]]
[[Category: Guentert P]]
[[Category: Kirchner, D K]]
[[Category: Henrich E]]
[[Category: Koepke, J]]
[[Category: Kirchner DK]]
[[Category: Kraas, F I]]
[[Category: Koepke J]]
[[Category: Loehr, F]]
[[Category: Kraas FI]]
[[Category: Marahiel, M A]]
[[Category: Loehr F]]
[[Category: Rahighi, S]]
[[Category: Marahiel MA]]
[[Category: Tufar, P]]
[[Category: Rahighi S]]
[[Category: Pcp: aminoacyl/peptidyl carrier]]
[[Category: Tufar P]]
[[Category: Sfp: coenzyme a binding]]
[[Category: Sfp: phosphopantetheine transferase]]
[[Category: Transport protein-transferase complex]]
Retrieved from "https://proteopedia.org/4mrt"