4ms0: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
Line 3: Line 3:
<StructureSection load='4ms0' size='340' side='right'caption='[[4ms0]], [[Resolution|resolution]] 1.79&Aring;' scene=''>
<StructureSection load='4ms0' size='340' side='right'caption='[[4ms0]], [[Resolution|resolution]] 1.79&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4ms0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MS0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MS0 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4ms0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MS0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MS0 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2ZX:6-CHLOROPYRIMIDINE-2,4-DIAMINE'>2ZX</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2ZX:6-CHLOROPYRIMIDINE-2,4-DIAMINE'>2ZX</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4mrw|4mrw]], [[4mrz|4mrz]], [[4msa|4msa]], [[4msc|4msc]], [[4mse|4mse]], [[4msh|4msh]], [[4msn|4msn]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ms0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ms0 OCA], [https://pdbe.org/4ms0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ms0 RCSB], [https://www.ebi.ac.uk/pdbsum/4ms0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ms0 ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PDE10A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ms0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ms0 OCA], [http://pdbe.org/4ms0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ms0 RCSB], [http://www.ebi.ac.uk/pdbsum/4ms0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ms0 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/PDE10_HUMAN PDE10_HUMAN]] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:17389385</ref>
[https://www.uniprot.org/uniprot/PDE10_HUMAN PDE10_HUMAN] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:17389385</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 22: Line 20:


==See Also==
==See Also==
*[[Phosphodiesterase|Phosphodiesterase]]
*[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Badger, J]]
[[Category: Badger J]]
[[Category: Chie-Leon, B]]
[[Category: Chie-Leon B]]
[[Category: Logan, C]]
[[Category: Logan C]]
[[Category: Nienaber, V]]
[[Category: Nienaber V]]
[[Category: Sridhar, V]]
[[Category: Sridhar V]]
[[Category: Fragment screening]]
[[Category: Hydrolase]]
[[Category: Hydrolase-hydrolase inhibitor complex]]
Retrieved from "https://proteopedia.org/4ms0"