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==Crystal structure of Bacillus subtilis GabR, an autorepressor and transcriptional activator of GabT==
==Crystal structure of Bacillus subtilis GabR, an autorepressor and transcriptional activator of GabT==
<StructureSection load='4n0b' size='340' side='right' caption='[[4n0b]], [[Resolution|resolution]] 2.71&Aring;' scene=''>
<StructureSection load='4n0b' size='340' side='right'caption='[[4n0b]], [[Resolution|resolution]] 2.71&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4n0b]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_globigii"_migula_1900 "bacillus globigii" migula 1900]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N0B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4N0B FirstGlance]. <br>
<table><tr><td colspan='2'>[[4n0b]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N0B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4N0B FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=LLP:(2S)-2-AMINO-6-[[3-HYDROXY-2-METHYL-5-(PHOSPHONOOXYMETHYL)PYRIDIN-4-YL]METHYLIDENEAMINO]HEXANOIC+ACID'>LLP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=LLP:(2S)-2-AMINO-6-[[3-HYDROXY-2-METHYL-5-(PHOSPHONOOXYMETHYL)PYRIDIN-4-YL]METHYLIDENEAMINO]HEXANOIC+ACID'>LLP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4n0b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n0b OCA], [https://pdbe.org/4n0b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4n0b RCSB], [https://www.ebi.ac.uk/pdbsum/4n0b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4n0b ProSAT]</span></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4mgr|4mgr]]</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">gabR, ycnF, BSU03890 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 "Bacillus globigii" Migula 1900])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4n0b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n0b OCA], [http://pdbe.org/4n0b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4n0b RCSB], [http://www.ebi.ac.uk/pdbsum/4n0b PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4n0b ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/GABR_BACSU GABR_BACSU]] Activates the transcription of the gabTD operon. Is also a repressor of its own expression, both in the presence and absence of GABA. Binds specifically to the DNA region overlapping the -35 region of the gabT promoter and the -10 and +1 regions of the gabR promoter. Principally regulates the utilization of gamma-aminobutyrate.<ref>PMID:12123465</ref> <ref>PMID:15223311</ref>
[https://www.uniprot.org/uniprot/GABR_BACSU GABR_BACSU] Activates the transcription of the gabTD operon. Is also a repressor of its own expression, both in the presence and absence of GABA. Binds specifically to the DNA region overlapping the -35 region of the gabT promoter and the -10 and +1 regions of the gabR promoter. Principally regulates the utilization of gamma-aminobutyrate.<ref>PMID:12123465</ref> <ref>PMID:15223311</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bacillus globigii migula 1900]]
[[Category: Bacillus subtilis]]
[[Category: Bach, A]]
[[Category: Large Structures]]
[[Category: Belitsky, B R]]
[[Category: Bach A]]
[[Category: Edayathumangalam, R]]
[[Category: Belitsky BR]]
[[Category: Garcia, R]]
[[Category: Edayathumangalam R]]
[[Category: Hoang, Q Q]]
[[Category: Garcia R]]
[[Category: Kreinbring, C A]]
[[Category: Hoang QQ]]
[[Category: Liao, J]]
[[Category: Kreinbring CA]]
[[Category: Liu, D]]
[[Category: Liao J]]
[[Category: Petsko, G A]]
[[Category: Liu D]]
[[Category: Ringe, D]]
[[Category: Petsko GA]]
[[Category: Stone, T]]
[[Category: Ringe D]]
[[Category: Terwilliger, T]]
[[Category: Stone T]]
[[Category: Wang, W]]
[[Category: Terwilliger T]]
[[Category: Wang, Y]]
[[Category: Wang W]]
[[Category: Wu, R]]
[[Category: Wang Y]]
[[Category: Activator]]
[[Category: Wu R]]
[[Category: Autorepressor]]
[[Category: Transcription activator]]
[[Category: Transcription factor]]
[[Category: Type-i aminotransferase-like fold]]
[[Category: Winged helix domain]]
Retrieved from "https://proteopedia.org/4n0b"