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==Crystal structure of plasmodium falciparum oxidized glutaredoxin 1 (PfGrx1) complexed with cisplatin==
==Crystal structure of plasmodium falciparum oxidized glutaredoxin 1 (PfGrx1) complexed with cisplatin==
<StructureSection load='4n10' size='340' side='right' caption='[[4n10]], [[Resolution|resolution]] 1.87&Aring;' scene=''>
<StructureSection load='4n10' size='340' side='right'caption='[[4n10]], [[Resolution|resolution]] 1.87&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4n10]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plaf7 Plaf7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N10 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4N10 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4n10]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_3D7 Plasmodium falciparum 3D7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N10 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4N10 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CPT:CISPLATIN'>CPT</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=MPO:3[N-MORPHOLINO]PROPANE+SULFONIC+ACID'>MPO</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CPT:CISPLATIN'>CPT</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=MPO:3[N-MORPHOLINO]PROPANE+SULFONIC+ACID'>MPO</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4hjm|4hjm]], [[4mzb|4mzb]], [[4mzc|4mzc]], [[1kte|1kte]], [[3c1r|3c1r]], [[3ctg|3ctg]], [[4n0z|4n0z]], [[4n11|4n11]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4n10 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n10 OCA], [https://pdbe.org/4n10 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4n10 RCSB], [https://www.ebi.ac.uk/pdbsum/4n10 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4n10 ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">GRX1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=36329 PLAF7])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Arsenate_reductase_(glutaredoxin) Arsenate reductase (glutaredoxin)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.20.4.1 1.20.4.1] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4n10 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n10 OCA], [http://pdbe.org/4n10 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4n10 RCSB], [http://www.ebi.ac.uk/pdbsum/4n10 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4n10 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q9NLB2_PLAF7 Q9NLB2_PLAF7]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Plaf7]]
[[Category: Large Structures]]
[[Category: Sharma, A]]
[[Category: Plasmodium falciparum 3D7]]
[[Category: Yogavel, M]]
[[Category: Sharma A]]
[[Category: Active site]]
[[Category: Yogavel M]]
[[Category: Cisplatin]]
[[Category: Glutathione]]
[[Category: Oxidoreductase]]
[[Category: Pt-sad]]
[[Category: Redox enzyme]]
[[Category: Trx fold]]

Revision as of 10:25, 28 December 2022

Crystal structure of plasmodium falciparum oxidized glutaredoxin 1 (PfGrx1) complexed with cisplatin

4n10, resolution 1.87Å

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