4n6q: Difference between revisions
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<StructureSection load='4n6q' size='340' side='right'caption='[[4n6q]], [[Resolution|resolution]] 1.79Å' scene=''> | <StructureSection load='4n6q' size='340' side='right'caption='[[4n6q]], [[Resolution|resolution]] 1.79Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4n6q]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[4n6q]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Aspergillus_nidulans Aspergillus nidulans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N6Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4N6Q FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4n6q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n6q OCA], [https://pdbe.org/4n6q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4n6q RCSB], [https://www.ebi.ac.uk/pdbsum/4n6q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4n6q ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/VOSA_EMENI VOSA_EMENI] Component of the velB-VosA heterodimeric complex that plays a dual role in activating genes associated with spore maturation and repressing certain development-associated genes (PubMed:17912349, PubMed:21152013, PubMed:23049895, PubMed:24391470). Controls primarily the late process of sporulation including trehalose biogenesis (PubMed:17912349). The complex binds DNA through the DNA-binding domain of vosA that recognizes an 11-nucleotide consensus sequence 5'-CTGGCCGCGGC-3' consisting of two motifs in the promoters of key developmental regulatory genes (PubMed:24391470). The vosA-velB complex binds to the beta-glucan synthase fksA gene promoter in asexual spores for repression (PubMed:25960370).[UniProtKB:A0SP16]<ref>PMID:17912349</ref> <ref>PMID:21152013</ref> <ref>PMID:23049895</ref> <ref>PMID:25960370</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Aspergillus nidulans]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Ahmed | [[Category: Ahmed YL]] | ||
[[Category: Dickmanns | [[Category: Dickmanns A]] | ||
[[Category: Ficner | [[Category: Ficner R]] | ||
[[Category: Neumann | [[Category: Neumann P]] | ||
