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==Crystal structure of eukaryotic THIC from A. thaliana==
==Crystal structure of eukaryotic THIC from A. thaliana==
<StructureSection load='4n7q' size='340' side='right' caption='[[4n7q]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
<StructureSection load='4n7q' size='340' side='right'caption='[[4n7q]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4n7q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N7Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4N7Q FirstGlance]. <br>
<table><tr><td colspan='2'>[[4n7q]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N7Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4N7Q FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=HEZ:HEXANE-1,6-DIOL'>HEZ</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=HEZ:HEXANE-1,6-DIOL'>HEZ</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">THIC, PY, At2g29630, T27A16.27 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4n7q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n7q OCA], [https://pdbe.org/4n7q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4n7q RCSB], [https://www.ebi.ac.uk/pdbsum/4n7q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4n7q ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphomethylpyrimidine_synthase Phosphomethylpyrimidine synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.99.17 4.1.99.17] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4n7q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n7q OCA], [http://pdbe.org/4n7q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4n7q RCSB], [http://www.ebi.ac.uk/pdbsum/4n7q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4n7q ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/THIC_ARATH THIC_ARATH]] Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.<ref>PMID:18048325</ref> <ref>PMID:18332905</ref>
[https://www.uniprot.org/uniprot/THIC_ARATH THIC_ARATH] Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.<ref>PMID:18048325</ref> <ref>PMID:18332905</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Arath]]
[[Category: Arabidopsis thaliana]]
[[Category: Phosphomethylpyrimidine synthase]]
[[Category: Large Structures]]
[[Category: Begley, T P]]
[[Category: Begley TP]]
[[Category: Coquille, S C]]
[[Category: Coquille SC]]
[[Category: Fitzpatrick, T B]]
[[Category: Fitzpatrick TB]]
[[Category: Mehta, A]]
[[Category: Mehta A]]
[[Category: Roux, C]]
[[Category: Roux C]]
[[Category: Thore, S]]
[[Category: Thore S]]
[[Category: Hmp-p synthase]]
[[Category: Lyase]]
[[Category: Metal binding site]]
[[Category: Sam radical dependent enzyme]]
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