4n84: Difference between revisions

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==Crystal structure of 14-3-3zeta in complex with a 12-carbon-linker cyclic peptide derived from ExoS==
==Crystal structure of 14-3-3zeta in complex with a 12-carbon-linker cyclic peptide derived from ExoS==
<StructureSection load='4n84' size='340' side='right' caption='[[4n84]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
<StructureSection load='4n84' size='340' side='right'caption='[[4n84]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4n84]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N84 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4N84 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4n84]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N84 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4N84 FirstGlance]. <br>
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MKD:(2S)-2-AMINO-2-METHYLOCTANOIC+ACID'>MKD</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MKD:(2S)-2-AMINO-2-METHYLOCTANOIC+ACID'>MKD</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ihl|4ihl]], [[3ch8|3ch8]], [[3nkx|3nkx]], [[4iea|4iea]], [[4n7g|4n7g]], [[4n7y|4n7y]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4n84 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n84 OCA], [https://pdbe.org/4n84 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4n84 RCSB], [https://www.ebi.ac.uk/pdbsum/4n84 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4n84 ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NP_001129171.1, YWHAZ ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4n84 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n84 OCA], [http://pdbe.org/4n84 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4n84 RCSB], [http://www.ebi.ac.uk/pdbsum/4n84 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4n84 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/1433Z_HUMAN 1433Z_HUMAN]] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.<ref>PMID:9360956</ref> <ref>PMID:14578935</ref> <ref>PMID:15071501</ref> <ref>PMID:15644438</ref> <ref>PMID:16376338</ref>
[https://www.uniprot.org/uniprot/1433Z_HUMAN 1433Z_HUMAN] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.<ref>PMID:9360956</ref> <ref>PMID:14578935</ref> <ref>PMID:15071501</ref> <ref>PMID:15644438</ref> <ref>PMID:16376338</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
*[[14-3-3 protein|14-3-3 protein]]
*[[14-3-3 protein 3D structures|14-3-3 protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Bier, D]]
[[Category: Large Structures]]
[[Category: Glas, A]]
[[Category: Pseudomonas aeruginosa]]
[[Category: Grossmann, T]]
[[Category: Bier D]]
[[Category: Hahne, G]]
[[Category: Glas A]]
[[Category: Ottmann, C]]
[[Category: Grossmann T]]
[[Category: 14-3-3]]
[[Category: Hahne G]]
[[Category: Adaptor protein]]
[[Category: Ottmann C]]
[[Category: Cross-link]]
[[Category: Protein-protein interaction]]
[[Category: Signaling protein]]
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