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==Crystal structure of M. tuberculosis DprE1 in complex with PBTZ169==
==Crystal structure of M. tuberculosis DprE1 in complex with PBTZ169==
<StructureSection load='4ncr' size='340' side='right' caption='[[4ncr]], [[Resolution|resolution]] 1.88&Aring;' scene=''>
<StructureSection load='4ncr' size='340' side='right'caption='[[4ncr]], [[Resolution|resolution]] 1.88&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4ncr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NCR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NCR FirstGlance]. <br>
<table><tr><td colspan='2'>[[4ncr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NCR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NCR FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=26J:2-(4-(CYCLOHEXYLMETHYL)PIPERAZIN-1-YL)-8-NITRO-6-(TRIFLUOROMETHYL)-4H-BENZO[E][1,3]THIAZIN-4-ONE,+BOUND+FORM'>26J</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=26J:2-(4-(CYCLOHEXYLMETHYL)PIPERAZIN-1-YL)-8-NITRO-6-(TRIFLUOROMETHYL)-4H-BENZO[E][1,3]THIAZIN-4-ONE,+BOUND+FORM'>26J</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4fdp|4fdp]], [[4f4q|4f4q]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ncr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ncr OCA], [https://pdbe.org/4ncr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ncr RCSB], [https://www.ebi.ac.uk/pdbsum/4ncr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ncr ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">dprE1, MT3898, Rv3790 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 MYCTU])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ncr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ncr OCA], [http://pdbe.org/4ncr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ncr RCSB], [http://www.ebi.ac.uk/pdbsum/4ncr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ncr ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/DPRE1_MYCTU DPRE1_MYCTU]] Involved in the epimerization of decaprenylphosphoryl ribose (DPR) to decaprenylphosphoryl arabinose (DPA) a precursor for arabinan synthesis in mycobacterial cell wall biosynthesis. Probably catalyzes the oxidation at C-2 of decaprenylphosphoryl ribose (DPR) to yield decaprenylphosphoryl 2-keto-ribose (DPX).<ref>PMID:16291675</ref>
[https://www.uniprot.org/uniprot/DPRE1_MYCTU DPRE1_MYCTU] Involved in the epimerization of decaprenylphosphoryl ribose (DPR) to decaprenylphosphoryl arabinose (DPA) a precursor for arabinan synthesis in mycobacterial cell wall biosynthesis. Probably catalyzes the oxidation at C-2 of decaprenylphosphoryl ribose (DPR) to yield decaprenylphosphoryl 2-keto-ribose (DPX).<ref>PMID:16291675</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Myctu]]
[[Category: Large Structures]]
[[Category: Cole, S T]]
[[Category: Mycobacterium tuberculosis H37Rv]]
[[Category: Neres, J]]
[[Category: Cole ST]]
[[Category: Pojer, F]]
[[Category: Neres J]]
[[Category: Decaprenylphosphoryl-beta-d-ribose oxidase]]
[[Category: Pojer F]]
[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]

Revision as of 08:22, 11 January 2023

Crystal structure of M. tuberculosis DprE1 in complex with PBTZ169

4ncr, resolution 1.88Å

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