4nfi: Difference between revisions

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<StructureSection load='4nfi' size='340' side='right'caption='[[4nfi]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
<StructureSection load='4nfi' size='340' side='right'caption='[[4nfi]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4nfi]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NFI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NFI FirstGlance]. <br>
<table><tr><td colspan='2'>[[4nfi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NFI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NFI FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=JD5:[({5-[4-(CYCLOPROPYLOXY)PHENYL]PYRIDIN-3-YL}AMINO)METHANEDIYL]BIS(PHOSPHONIC+ACID)'>JD5</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=JD5:[({5-[4-(CYCLOPROPYLOXY)PHENYL]PYRIDIN-3-YL}AMINO)METHANEDIYL]BIS(PHOSPHONIC+ACID)'>JD5</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4nfj|4nfj]], [[4nfk|4nfk]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nfi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nfi OCA], [https://pdbe.org/4nfi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nfi RCSB], [https://www.ebi.ac.uk/pdbsum/4nfi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nfi ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nfi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nfi OCA], [http://pdbe.org/4nfi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4nfi RCSB], [http://www.ebi.ac.uk/pdbsum/4nfi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4nfi ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/FPPS_HUMAN FPPS_HUMAN]] Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.  
[https://www.uniprot.org/uniprot/FPPS_HUMAN FPPS_HUMAN] Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Berghuis, A M]]
[[Category: Berghuis AM]]
[[Category: Park, J]]
[[Category: De Schutter JW]]
[[Category: Schutter, J W.De]]
[[Category: Park J]]
[[Category: Tsantrizos, Y S]]
[[Category: Tsantrizos YS]]
[[Category: Transferase-transferase inhibitor complex]]
Retrieved from "https://proteopedia.org/4nfi"