4nfk: Difference between revisions

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<StructureSection load='4nfk' size='340' side='right'caption='[[4nfk]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
<StructureSection load='4nfk' size='340' side='right'caption='[[4nfk]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4nfk]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NFK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NFK FirstGlance]. <br>
<table><tr><td colspan='2'>[[4nfk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NFK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NFK FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=JD5:[({5-[4-(CYCLOPROPYLOXY)PHENYL]PYRIDIN-3-YL}AMINO)METHANEDIYL]BIS(PHOSPHONIC+ACID)'>JD5</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=JD5:[({5-[4-(CYCLOPROPYLOXY)PHENYL]PYRIDIN-3-YL}AMINO)METHANEDIYL]BIS(PHOSPHONIC+ACID)'>JD5</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4nfi|4nfi]], [[4nfj|4nfj]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nfk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nfk OCA], [https://pdbe.org/4nfk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nfk RCSB], [https://www.ebi.ac.uk/pdbsum/4nfk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nfk ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nfk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nfk OCA], [http://pdbe.org/4nfk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4nfk RCSB], [http://www.ebi.ac.uk/pdbsum/4nfk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4nfk ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/FPPS_HUMAN FPPS_HUMAN]] Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.  
[https://www.uniprot.org/uniprot/FPPS_HUMAN FPPS_HUMAN] Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Berghuis, A M]]
[[Category: Berghuis AM]]
[[Category: Park, J]]
[[Category: De schutter JW]]
[[Category: Tsantrizos, Y S]]
[[Category: Park J]]
[[Category: Schutter, J W.De]]
[[Category: Tsantrizos YS]]
[[Category: Transferase-transferase inhibitor complex]]
Retrieved from "https://proteopedia.org/4nfk"