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==Crystal structure of multidrug-resistant clinical isolate A02 HIV-1 protease in complex with tipranavir==
==Crystal structure of multidrug-resistant clinical isolate A02 HIV-1 protease in complex with tipranavir==
<StructureSection load='4nju' size='340' side='right' caption='[[4nju]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
<StructureSection load='4nju' size='340' side='right'caption='[[4nju]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4nju]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/9hiv1 9hiv1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NJU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NJU FirstGlance]. <br>
<table><tr><td colspan='2'>[[4nju]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NJU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NJU FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=TPV:N-(3-{(1R)-1-[(6R)-4-HYDROXY-2-OXO-6-PHENETHYL-6-PROPYL-5,6-DIHYDRO-2H-PYRAN-3-YL]PROPYL}PHENYL)-5-(TRIFLUOROMETHYL)-2-PYRIDINESULFONAMIDE'>TPV</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TPV:N-(3-{(1R)-1-[(6R)-4-HYDROXY-2-OXO-6-PHENETHYL-6-PROPYL-5,6-DIHYDRO-2H-PYRAN-3-YL]PROPYL}PHENYL)-5-(TRIFLUOROMETHYL)-2-PYRIDINESULFONAMIDE'>TPV</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4njs|4njs]], [[4njt|4njt]], [[4njv|4njv]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nju FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nju OCA], [https://pdbe.org/4nju PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nju RCSB], [https://www.ebi.ac.uk/pdbsum/4nju PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nju ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">pol ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 9HIV1])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nju FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nju OCA], [http://pdbe.org/4nju PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4nju RCSB], [http://www.ebi.ac.uk/pdbsum/4nju PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4nju ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q9J006_9HIV1 Q9J006_9HIV1]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4nju" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4nju" style="background-color:#fffaf0;"></div>
==See Also==
*[[Immunodeficiency virus protease 3D structures|Immunodeficiency virus protease 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Das, D]]
[[Category: Human immunodeficiency virus 1]]
[[Category: Garimella, H]]
[[Category: Large Structures]]
[[Category: Kaufman, J D]]
[[Category: Das D]]
[[Category: Mitsuya, H]]
[[Category: Garimella H]]
[[Category: Wingfield, P T]]
[[Category: Kaufman JD]]
[[Category: Yedidi, R S]]
[[Category: Mitsuya H]]
[[Category: Hiv-1 protease]]
[[Category: Wingfield PT]]
[[Category: Hydrolase-hydrolase inhibitor complex]]
[[Category: Yedidi RS]]
[[Category: Multidrug-resistance]]
[[Category: Protease inhibitor]]
[[Category: Tipranavir]]
[[Category: Tpv]]
Retrieved from "https://proteopedia.org/4nju"