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==Cytokine receptor complex - Crystal form 2==
==Cytokine receptor complex - Crystal form 2==
<StructureSection load='4nn7' size='340' side='right' caption='[[4nn7]], [[Resolution|resolution]] 3.77&Aring;' scene=''>
<StructureSection load='4nn7' size='340' side='right'caption='[[4nn7]], [[Resolution|resolution]] 3.77&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4nn7]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NN7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NN7 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4nn7]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NN7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NN7 FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4nn5|4nn5]], [[4nn6|4nn6]]</td></tr>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nn7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nn7 OCA], [https://pdbe.org/4nn7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nn7 RCSB], [https://www.ebi.ac.uk/pdbsum/4nn7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nn7 ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Tslp ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), Il7r, IL7RA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), Crlf2, CRLF2 (TSLPR), Crlm2, Tpte2, Tslpr ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nn7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nn7 OCA], [http://pdbe.org/4nn7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4nn7 RCSB], [http://www.ebi.ac.uk/pdbsum/4nn7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4nn7 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/TSLP_MOUSE TSLP_MOUSE]] Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c(+) dendritic cells. Can induce allergic inflammation by directly activating mast cells (By similarity). [[http://www.uniprot.org/uniprot/CRLF2_MOUSE CRLF2_MOUSE]] Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2. Implicated in the development of the hematopoietic system. [[http://www.uniprot.org/uniprot/IL7RA_MOUSE IL7RA_MOUSE]] Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP).  
[https://www.uniprot.org/uniprot/TSLP_MOUSE TSLP_MOUSE] Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c(+) dendritic cells. Can induce allergic inflammation by directly activating mast cells (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
*[[Interleukin receptor|Interleukin receptor]]
*[[Interleukin receptor 3D structures|Interleukin receptor 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Lk3 transgenic mice]]
[[Category: Large Structures]]
[[Category: Savvides, S N]]
[[Category: Mus musculus]]
[[Category: Schie, L van]]
[[Category: Savvides SN]]
[[Category: Verstraete, K]]
[[Category: Verstraete K]]
[[Category: Cell surface]]
[[Category: Van Schie L]]
[[Category: Chr domain]]
[[Category: Cytokine-cytokine receptor complex]]
[[Category: Four helical bundle fold]]
[[Category: Tslp cytokine signaling]]
[[Category: Tslpr and il-7ralpha receptor]]
Retrieved from "https://proteopedia.org/4nn7"