4nok: Difference between revisions

<StructureSection load='4nok' size='340' side='right'caption='[[4nok]], [[Resolution|resolution]] 2.50&Aring;' scene=''>

<table><tr><td colspan='2'>[[4nok]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NOK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NOK FirstGlance]. <br>

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nok FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nok OCA], [https://pdbe.org/4nok PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nok RCSB], [https://www.ebi.ac.uk/pdbsum/4nok PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nok ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/LGMN_MOUSE LGMN_MOUSE] Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. May be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system. Required for normal lysosomal protein degradation in renal proximal tubules. Required for normal degradation of internalized EGFR. Plays a role in the regulation of cell proliferation via its role in EGFR degradation.<ref>PMID:9742219</ref> <ref>PMID:17350006</ref> <ref>PMID:21292981</ref>  

[[Category: Large Structures]]

[[Category: Mus musculus]]

[[Category: Ding W]]

[[Category: Hua T]]

[[Category: Jiao L]]

[[Category: Liu ZJ]]

[[Category: Ni X]]

[[Category: Ouyang S]]

[[Category: Qu L]]

[[Category: Ru H]]

[[Category: Shaw N]]

[[Category: Zhao L]]