4nph: Difference between revisions

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== Structural highlights ==

<table><tr><td colspan='2'>[[4nph]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Salty Salty~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NPH OCA]. For a guided tour on the structure components use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4NPH FirstGlance].

<table><tr><td colspan='2'>[[4nph]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium_str._LT2 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NPH OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=4NPH FirstGlance].

</td></tr><tr id='gene'><td class="sblockLbl">[[Gene|Gene:]]</td><td class="sblockDat">ssaN, STM1415 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=99287 SALTY])</td></tr>

</td></tr><tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=4nph FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nph OCA], [https://pdbe.org/4nph PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nph RCSB], [https://www.ebi.ac.uk/pdbsum/4nph PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nph ProSAT]</td></tr>

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/H(+)-transporting_two-sector_ATPase H(+)-transporting two-sector ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.14 3.6.3.14] </td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4nph FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nph OCA], [~~http~~://pdbe.org/4nph PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4nph RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4nph PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4nph ProSAT]</td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/SCTN2_SALTY SCTN2_SALTY] ATPase component of the type III secretion system (T3SS), also called injectisome, which is used to inject bacterial effector proteins into eukaryotic host cells (PubMed:24722491). Acts as a molecular motor to provide the energy that is required for the export of proteins (By similarity). Required for type III secretion apparatus (T3SA) formation, secretion of a subset of SPI-2 effectors and virulence (PubMed:24722491, PubMed:25035427). May play a critical role in T3SS substrate recognition, disassembly of the effector/chaperone complex and unfolding of the effector in an ATP-dependent manner prior to secretion (Probable). Releases the effector protein SseB from the T3SS-2 specific chaperone SsaE in an ATP-dependent manner (PubMed:24722491).[UniProtKB:P0A1B9]<ref>PMID:24722491</ref> <ref>PMID:25035427</ref> <ref>PMID:24722491</ref> <ref>PMID:25035427</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: ~~Salty~~]]

[[Category: Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]]

[[Category: Coombes~~, B K~~]]

[[Category: Coombes BK]]

[[Category: Cooper~~, C A~~]]

[[Category: Cooper CA]]

[[Category: Junop~~, M S~~]]

[[Category: Junop MS]]

[[Category: Sugiman-Marangos~~, S N~~]]

[[Category: Sugiman-Marangos SN]]

[[Category: Zhang, K]]

[[Category: Zhang K]]

~~[[Category: Atpase]]~~

~~[[Category: Protein transport]]~~

~~[[Category: T3ss~~]]

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@@ Line 3: / Line 3: @@
 <StructureSection load='4nph' size='340' side='right'caption='[[4nph]], [[Resolution|resolution]] 2.09&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4nph]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Salty Salty]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NPH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NPH FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4nph]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium_str._LT2 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NPH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NPH FirstGlance]. <br>
-</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ssaN, STM1415 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=99287 SALTY])</td></tr>
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nph FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nph OCA], [https://pdbe.org/4nph PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nph RCSB], [https://www.ebi.ac.uk/pdbsum/4nph PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nph ProSAT]</span></td></tr>
-<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/H(+)-transporting_two-sector_ATPase H(+)-transporting two-sector ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.14 3.6.3.14] </span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nph FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nph OCA], [http://pdbe.org/4nph PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4nph RCSB], [http://www.ebi.ac.uk/pdbsum/4nph PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4nph ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/SCTN2_SALTY SCTN2_SALTY] ATPase component of the type III secretion system (T3SS), also called injectisome, which is used to inject bacterial effector proteins into eukaryotic host cells (PubMed:24722491). Acts as a molecular motor to provide the energy that is required for the export of proteins (By similarity). Required for type III secretion apparatus (T3SA) formation, secretion of a subset of SPI-2 effectors and virulence (PubMed:24722491, PubMed:25035427). May play a critical role in T3SS substrate recognition, disassembly of the effector/chaperone complex and unfolding of the effector in an ATP-dependent manner prior to secretion (Probable). Releases the effector protein SseB from the T3SS-2 specific chaperone SsaE in an ATP-dependent manner (PubMed:24722491).[UniProtKB:P0A1B9]<ref>PMID:24722491</ref> <ref>PMID:25035427</ref> <ref>PMID:24722491</ref> <ref>PMID:25035427</ref>
+== References ==
+<references/>
 __TOC__
 </StructureSection>
 [[Category: Large Structures]]
-[[Category: Salty]]
+[[Category: Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]]
-[[Category: Coombes, B K]]
+[[Category: Coombes BK]]
-[[Category: Cooper, C A]]
+[[Category: Cooper CA]]
-[[Category: Junop, M S]]
+[[Category: Junop MS]]
-[[Category: Sugiman-Marangos, S N]]
+[[Category: Sugiman-Marangos SN]]
-[[Category: Zhang, K]]
+[[Category: Zhang K]]
-[[Category: Atpase]]
-[[Category: Protein transport]]
-[[Category: T3ss]]