7qui: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 7qui is ~~ON HOLD until Paper Publication~~

==Crystal structure of the N-terminal domain of Siglec-8 in complex with sulfonamide sialoside analogue==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[7qui]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7QUI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7QUI FirstGlance]. <br>

~~Description~~:

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=F9I:(2~{S},4~{S},5~{R},6~{R})-5-acetamido-2-[(2~{S},3~{R},4~{S},5~{S},6~{R})-2-[(2~{R},3~{S},4~{R},5~{R},6~{R})-5-acetamido-2-(hydroxymethyl)-4,6-bis(oxidanyl)oxan-3-yl]oxy-3,5-bis(oxidanyl)-6-(sulfooxymethyl)oxan-4-yl]oxy-6-[(1~{R},2~{R})-3-(naphthalen-2-ylsulfonylamino)-1,2-bis(oxidanyl)propyl]-4-oxidanyl-oxane-2-carboxylic+acid'>F9I</scene></td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7qui FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7qui OCA], [https://pdbe.org/7qui PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7qui RCSB], [https://www.ebi.ac.uk/pdbsum/7qui PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7qui ProSAT]</span></td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/SIGL8_HUMAN SIGL8_HUMAN] Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3-linked sialic acid. Also binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Atxabal U]]

[[Category: Delgado S]]

[[Category: Ereno-Orbea J]]

[[Category: Franconetti A]]

[[Category: Jimenez-Barbero J]]

[[Category: Lenza MP]]

[[Category: Nycholat C]]

[[Category: Oyenarte I]]

[[Category: Paulson J]]

[[Category: Quintana JI]]

[[Category: Unione L]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 7qui is ON HOLD  until Paper Publication
+==Crystal structure of the N-terminal domain of Siglec-8 in complex with sulfonamide sialoside analogue==
+<StructureSection load='7qui' size='340' side='right'caption='[[7qui]], [[Resolution|resolution]] 3.35&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[7qui]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7QUI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7QUI FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=F9I:(2~{S},4~{S},5~{R},6~{R})-5-acetamido-2-[(2~{S},3~{R},4~{S},5~{S},6~{R})-2-[(2~{R},3~{S},4~{R},5~{R},6~{R})-5-acetamido-2-(hydroxymethyl)-4,6-bis(oxidanyl)oxan-3-yl]oxy-3,5-bis(oxidanyl)-6-(sulfooxymethyl)oxan-4-yl]oxy-6-[(1~{R},2~{R})-3-(naphthalen-2-ylsulfonylamino)-1,2-bis(oxidanyl)propyl]-4-oxidanyl-oxane-2-carboxylic+acid'>F9I</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7qui FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7qui OCA], [https://pdbe.org/7qui PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7qui RCSB], [https://www.ebi.ac.uk/pdbsum/7qui PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7qui ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/SIGL8_HUMAN SIGL8_HUMAN] Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3-linked sialic acid. Also binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Atxabal U]]
+[[Category: Delgado S]]
+[[Category: Ereno-Orbea J]]
+[[Category: Franconetti A]]
+[[Category: Jimenez-Barbero J]]
+[[Category: Lenza MP]]
+[[Category: Nycholat C]]
+[[Category: Oyenarte I]]
+[[Category: Paulson J]]
+[[Category: Quintana JI]]
+[[Category: Unione L]]