8f0w: Difference between revisions
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==Tudor Domain of Tumor suppressor p53BP1 with MFP-5956== | |||
<StructureSection load='8f0w' size='340' side='right'caption='[[8f0w]], [[Resolution|resolution]] 1.52Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8f0w]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8F0W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8F0W FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=X9N:1-[4-(4-ethylpiperazin-1-yl)-3-fluorophenyl]butan-1-one'>X9N</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8f0w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8f0w OCA], [https://pdbe.org/8f0w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8f0w RCSB], [https://www.ebi.ac.uk/pdbsum/8f0w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8f0w ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: | == Disease == | ||
[[Category: | [https://www.uniprot.org/uniprot/TP53B_HUMAN TP53B_HUMAN] Note=A chromosomal aberration involving TP53BP1 is found in a form of myeloproliferative disorder chronic with eosinophilia. Translocation t(5;15)(q33;q22) with PDGFRB creating a TP53BP1-PDGFRB fusion protein. | ||
[[Category: | == Function == | ||
[[Category: | [https://www.uniprot.org/uniprot/TP53B_HUMAN TP53B_HUMAN] Plays a key role in the response to DNA damage. May have a role in checkpoint signaling during mitosis. Enhances TP53-mediated transcriptional activation.<ref>PMID:12364621</ref> <ref>PMID:17190600</ref> | ||
[[Category: Dong | == References == | ||
[[Category: | <references/> | ||
[[Category: | __TOC__ | ||
[[Category: | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Arrowsmith CH]] | ||
[[Category: Bountra C]] | |||
[[Category: Brown PJ]] | |||
[[Category: Doak B]] | |||
[[Category: Dong A]] | |||
[[Category: Edwards AM]] | |||
[[Category: Gunzburg M]] | |||
[[Category: Headey S]] | |||
[[Category: Hong Z]] | |||
[[Category: James LI]] | |||
[[Category: The J]] | |||
Revision as of 07:33, 18 January 2023
Tudor Domain of Tumor suppressor p53BP1 with MFP-5956
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