2kv2: Difference between revisions

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==Solution Structure of the human BLM HRDC domain==

== Structural highlights ==

<table><tr><td colspan='2'>[[2kv2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KV2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KV2 FirstGlance]. <br>

<table><tr><td colspan='2'>[[2kv2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KV2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KV2 FirstGlance]. <br>

</td></tr>~~<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BLM ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>~~

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kv2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kv2 OCA], [https://pdbe.org/2kv2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kv2 RCSB], [https://www.ebi.ac.uk/pdbsum/2kv2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kv2 ProSAT]</span></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kv2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kv2 OCA], [https://pdbe.org/2kv2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kv2 RCSB], [https://www.ebi.ac.uk/pdbsum/2kv2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kv2 ProSAT]</span></td></tr>

</table>

== Disease ==

[[https://www.uniprot.org/uniprot/BLM_HUMAN BLM_HUMAN]] Bloom syndrome. The disease is caused by mutations affecting the gene represented in this entry.

[https://www.uniprot.org/uniprot/BLM_HUMAN BLM_HUMAN] Bloom syndrome. The disease is caused by mutations affecting the gene represented in this entry.

== Function ==

[[https://www.uniprot.org/uniprot/BLM_HUMAN BLM_HUMAN]] Participates in DNA replication and repair. Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction. Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA. Negatively regulates sister chromatid exchange (SCE).<ref>PMID:9388193</ref> <ref>PMID:12019152</ref> <ref>PMID:21325134</ref> <ref>PMID:23509288</ref>

[https://www.uniprot.org/uniprot/BLM_HUMAN BLM_HUMAN] Participates in DNA replication and repair. Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction. Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA. Negatively regulates sister chromatid exchange (SCE).<ref>PMID:9388193</ref> <ref>PMID:12019152</ref> <ref>PMID:21325134</ref> <ref>PMID:23509288</ref>

== Publication Abstract from PubMed ==

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__TOC__

</StructureSection>

[[Category: ~~Human~~]]

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Choi, B S]]

[[Category: Choi B-S]]

[[Category: Kim~~, Y M]]~~

[[Category: Kim YM]]

~~[[Category: Bloom syndrome]]~~

~~[[Category: Disease mutation]]~~

~~[[Category: Dna replication]]~~

~~[[Category: Dna-binding]]~~

~~[[Category: Gene regulation]]~~

~~[[Category: Hrdc domain]]~~

~~[[Category: Nucleotide-binding]]~~

~~[[Category: Nucleus~~]]

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@@ Line 1: / Line 1: @@
 ==Solution Structure of the human BLM HRDC domain==
-<StructureSection load='2kv2' size='340' side='right'caption='[[2kv2]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
+<StructureSection load='2kv2' size='340' side='right'caption='[[2kv2]]' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2kv2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KV2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KV2 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2kv2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KV2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KV2 FirstGlance]. <br>
-</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BLM ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kv2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kv2 OCA], [https://pdbe.org/2kv2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kv2 RCSB], [https://www.ebi.ac.uk/pdbsum/2kv2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kv2 ProSAT]</span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kv2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kv2 OCA], [https://pdbe.org/2kv2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kv2 RCSB], [https://www.ebi.ac.uk/pdbsum/2kv2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kv2 ProSAT]</span></td></tr>
 </table>
 == Disease ==
-[[https://www.uniprot.org/uniprot/BLM_HUMAN BLM_HUMAN]] Bloom syndrome. The disease is caused by mutations affecting the gene represented in this entry.
+[https://www.uniprot.org/uniprot/BLM_HUMAN BLM_HUMAN] Bloom syndrome. The disease is caused by mutations affecting the gene represented in this entry.
 == Function ==
-[[https://www.uniprot.org/uniprot/BLM_HUMAN BLM_HUMAN]] Participates in DNA replication and repair. Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction. Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA. Negatively regulates sister chromatid exchange (SCE).<ref>PMID:9388193</ref> <ref>PMID:12019152</ref> <ref>PMID:21325134</ref> <ref>PMID:23509288</ref>
+[https://www.uniprot.org/uniprot/BLM_HUMAN BLM_HUMAN] Participates in DNA replication and repair. Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction. Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA. Negatively regulates sister chromatid exchange (SCE).<ref>PMID:9388193</ref> <ref>PMID:12019152</ref> <ref>PMID:21325134</ref> <ref>PMID:23509288</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 24: / Line 23: @@
 __TOC__
 </StructureSection>
-[[Category: Human]]
+[[Category: Homo sapiens]]
 [[Category: Large Structures]]
-[[Category: Choi, B S]]
+[[Category: Choi B-S]]
-[[Category: Kim, Y M]]
+[[Category: Kim YM]]
-[[Category: Bloom syndrome]]
-[[Category: Disease mutation]]
-[[Category: Dna replication]]
-[[Category: Dna-binding]]
-[[Category: Gene regulation]]
-[[Category: Hrdc domain]]
-[[Category: Nucleotide-binding]]
-[[Category: Nucleus]]