1jnp: Difference between revisions
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
[[Image:1jnp.jpg|left|200px]] | [[Image:1jnp.jpg|left|200px]] | ||
<!-- | |||
The line below this paragraph, containing "STRUCTURE_1jnp", creates the "Structure Box" on the page. | |||
You may change the PDB parameter (which sets the PDB file loaded into the applet) | |||
| | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | ||
| | or leave the SCENE parameter empty for the default display. | ||
--> | |||
{{STRUCTURE_1jnp| PDB=1jnp | SCENE= }} | |||
}} | |||
'''Crystal Structure of Murine Tcl1 at 2.5 Resolution''' | '''Crystal Structure of Murine Tcl1 at 2.5 Resolution''' | ||
| Line 32: | Line 29: | ||
[[Category: Wang, Y F.]] | [[Category: Wang, Y F.]] | ||
[[Category: Weber, I T.]] | [[Category: Weber, I T.]] | ||
[[Category: | [[Category: Beta barrel]] | ||
[[Category: | [[Category: Dimer]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:27:58 2008'' | |||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | |||
Revision as of 18:27, 2 May 2008
Crystal Structure of Murine Tcl1 at 2.5 Resolution
Overview
Tcl1 and Mtcp1, members of the Tcl1 family, are implicated in T-cell prolymphocytic leukemia. The crystal structure of a dimer of murine Tcl1 has been determined at 2.5 A resolution with an R factor of 0.225. Murine Tcl1, human Tcl1 and Mtcp1 share very similar subunit structures, with RMS differences of 0.6 and 1.4 A for C(alpha) atoms, respectively, while the sequences share 50 and 36% identity, respectively. These structures fold into an eight-stranded beta-barrel of unique topology and high internal symmetry of 1.1-1.3 A for the two halves of human and murine Tcl1 and 1.7 A for Mtcp1, despite the low 12-13% sequence identity. The molecular surfaces of all three structures showed a common planar region which is likely to be involved in protein-protein interactions.
About this Structure
1JNP is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
Structure of murine Tcl1 at 2.5 A resolution and implications for the TCL oncogene family., Petock JM, Torshin IY, Wang YF, Du Bois GC, Croce CM, Harrison RW, Weber IT, Acta Crystallogr D Biol Crystallogr. 2001 Nov;57(Pt 11):1545-51. Epub 2001, Oct 25. PMID:11679718 Page seeded by OCA on Fri May 2 21:27:58 2008
