4ntj: Difference between revisions

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==Structure of the human P2Y12 receptor in complex with an antithrombotic drug==
==Structure of the human P2Y12 receptor in complex with an antithrombotic drug==
<StructureSection load='4ntj' size='340' side='right' caption='[[4ntj]], [[Resolution|resolution]] 2.62&Aring;' scene=''>
<StructureSection load='4ntj' size='340' side='right'caption='[[4ntj]], [[Resolution|resolution]] 2.62&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4ntj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NTJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NTJ FirstGlance]. <br>
<table><tr><td colspan='2'>[[4ntj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NTJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NTJ FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AZJ:ETHYL+6-{4-[(BENZYLSULFONYL)CARBAMOYL]PIPERIDIN-1-YL}-5-CYANO-2-METHYLPYRIDINE-3-CARBOXYLATE'>AZJ</scene>, <scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AZJ:ETHYL+6-{4-[(BENZYLSULFONYL)CARBAMOYL]PIPERIDIN-1-YL}-5-CYANO-2-METHYLPYRIDINE-3-CARBOXYLATE'>AZJ</scene>, <scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">P2RY12, HORK3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ntj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ntj OCA], [https://pdbe.org/4ntj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ntj RCSB], [https://www.ebi.ac.uk/pdbsum/4ntj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ntj ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ntj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ntj OCA], [http://pdbe.org/4ntj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ntj RCSB], [http://www.ebi.ac.uk/pdbsum/4ntj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ntj ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
[[http://www.uniprot.org/uniprot/P2Y12_HUMAN P2Y12_HUMAN]] Resistance to clopidogrel in myocardial infarction, cerebrovascular accident, oblitering arteriopathy of the lower limbs;P2Y12 defect. The disease is caused by mutations affecting the gene represented in this entry.  
[https://www.uniprot.org/uniprot/P2Y12_HUMAN P2Y12_HUMAN] Resistance to clopidogrel in myocardial infarction, cerebrovascular accident, oblitering arteriopathy of the lower limbs;P2Y12 defect. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/P2Y12_HUMAN P2Y12_HUMAN]] Receptor for ADP and ATP coupled to G-proteins that inhibit the adenylyl cyclase second messenger system. Not activated by UDP and UTP. Involved in platelet aggregation.  
[https://www.uniprot.org/uniprot/C562_ECOLX C562_ECOLX] Electron-transport protein of unknown function.[https://www.uniprot.org/uniprot/P2Y12_HUMAN P2Y12_HUMAN] Receptor for ADP and ATP coupled to G-proteins that inhibit the adenylyl cyclase second messenger system. Not activated by UDP and UTP. Involved in platelet aggregation.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bacillus coli migula 1895]]
[[Category: Escherichia coli]]
[[Category: Cherezov, V]]
[[Category: Homo sapiens]]
[[Category: Fenalti, G]]
[[Category: Large Structures]]
[[Category: GPCR, GPCR Network]]
[[Category: Cherezov V]]
[[Category: Gao, Z G]]
[[Category: Fenalti G]]
[[Category: Han, G W]]
[[Category: Gao Z-G]]
[[Category: Jacobson, K A]]
[[Category: Han GW]]
[[Category: Jiang, H]]
[[Category: Jacobson KA]]
[[Category: Katritch, V]]
[[Category: Jiang H]]
[[Category: Kiselev, E]]
[[Category: Katritch V]]
[[Category: Lu, W]]
[[Category: Kiselev E]]
[[Category: Moss, S M]]
[[Category: Lu W]]
[[Category: Muller, C E]]
[[Category: Moss SM]]
[[Category: Paoletta, S]]
[[Category: Muller CE]]
[[Category: Stevens, R C]]
[[Category: Paoletta S]]
[[Category: Wu, B]]
[[Category: Stevens RC]]
[[Category: Yang, H]]
[[Category: Wu B]]
[[Category: Zhang, D]]
[[Category: Yang H]]
[[Category: Zhang, J]]
[[Category: Zhang D]]
[[Category: Zhang, K]]
[[Category: Zhang J]]
[[Category: Zhang, W]]
[[Category: Zhang K]]
[[Category: Zhao, Q]]
[[Category: Zhang W]]
[[Category: Zhu, L]]
[[Category: Zhao Q]]
[[Category: Antithrombotic drug]]
[[Category: Zhu L]]
[[Category: Gpcr]]
[[Category: Gpcr network]]
[[Category: Human p2y12 receptor]]
[[Category: Lipidic cubic phase]]
[[Category: Membrane]]
[[Category: Membrane protein]]
[[Category: Psi-biology]]
[[Category: Signaling protein]]
[[Category: Structural genomic]]
Retrieved from "https://proteopedia.org/4ntj"