7t94: Difference between revisions
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==Cryo-EM structure of S1 state ACh-bound M2R-Go signaling complex with a PAM== | |||
<StructureSection load='7t94' size='340' side='right'caption='[[7t94]], [[Resolution|resolution]] 3.16Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7t94]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7T94 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7T94 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2CU:3-AMINO-5-CHLORO-N-CYCLOPROPYL-4-METHYL-6-[2-(4-METHYLPIPERAZIN-1-YL)-2-OXOETHOXY]THIENO[2,3-B]PYRIDINE-2-CARBOXAMIDE'>2CU</scene>, <scene name='pdbligand=ACH:ACETYLCHOLINE'>ACH</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7t94 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7t94 OCA], [https://pdbe.org/7t94 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7t94 RCSB], [https://www.ebi.ac.uk/pdbsum/7t94 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7t94 ProSAT]</span></td></tr> | ||
</table> | |||
== Disease == | |||
[https://www.uniprot.org/uniprot/ACM2_HUMAN ACM2_HUMAN] Disease susceptibility is associated with variations affecting the gene represented in this entry. | |||
== Function == | |||
[https://www.uniprot.org/uniprot/ACM2_HUMAN ACM2_HUMAN] The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Mus musculus]] | |||
[[Category: Du Y]] | |||
[[Category: Kobilka BK]] | |||
[[Category: Wang Q]] | |||
[[Category: Xu J]] | |||
Revision as of 06:28, 25 January 2023
Cryo-EM structure of S1 state ACh-bound M2R-Go signaling complex with a PAM
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