7wiw: Difference between revisions
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==Cryo-EM structure of Mycobacterium tuberculosis irtAB complexed with ATP in an occluded conformation== | |||
<StructureSection load='7wiw' size='340' side='right'caption='[[7wiw]], [[Resolution|resolution]] 3.12Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7wiw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7WIW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7WIW FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7wiw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7wiw OCA], [https://pdbe.org/7wiw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7wiw RCSB], [https://www.ebi.ac.uk/pdbsum/7wiw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7wiw ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/IRTB_MYCTU IRTB_MYCTU] Part of the ABC transporter complex IrtAB involved in the import of iron-bound mycobactin (Fe-MBT) and carboxymycobactin (Fe-cMBT) (PubMed:16385031, PubMed:19948799) (By similarity). Transmembrane domains (TMD) form a pore in the membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity). Required for replication in human macrophages and in mouse lungs (PubMed:16385031).[UniProtKB:G7CBF6]<ref>PMID:16385031</ref> <ref>PMID:19948799</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Mycobacterium tuberculosis H37Rv]] | |||
[[Category: Rao Z]] | |||
[[Category: Sun S]] | |||
[[Category: Yang H]] | |||
[[Category: Zhang B]] | |||
Revision as of 06:31, 25 January 2023
Cryo-EM structure of Mycobacterium tuberculosis irtAB complexed with ATP in an occluded conformation
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